Safety of combining erythropoietin and melatonin for very preterm infants with brain bleeds

Who could benefit from this research

What this research studies

This project focuses on babies born very early who are at high risk for serious brain injury after intraventricular hemorrhage. Researchers are exploring whether giving two safe, familiar medicines together can influence how the brain and its fluid system develop and reduce the need for surgical treatment later on. The study builds on preclinical data showing potential benefits when the medications are given in a steady dosing pattern. If successful, this approach could offer a medical option to protect brain development and possibly reduce complications like hydrocephalus.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Robinson, Shenandoah — Johns Hopkins University
• Study coordinator: Robinson, Shenandoah

Related research

Other NIH-funded projects on the same topics.

• Brain fluid buildup and brain wiring after bleeding in very premature babies

  Sees if larger fluid-filled spaces and changes in brain connections are linked to thinking and movement problems in very premature babies who had brain bleeding.

  NIH research Washington University · Saint Louis, United States · NIH-11260195

• Understanding epilepsy risk in very preterm infants with brain hemorrhage

  This study is looking at how very premature babies who have serious bleeding in the brain might develop epilepsy and other developmental challenges, and it aims to find early signs that could help doctors identify these risks so they can provide better care and support for these little ones.

  NIH research Washington University · Saint Louis, United States · NIH-11080978

• Impact of brain fluid volume on neurological outcomes in preterm infants with bleeding

  This study looks at how the amount of fluid in the brains of very preterm babies with brain bleeding affects their development and thinking skills, with the hope of finding ways to help them grow and learn better.

  NIH research Washington University · Saint Louis, United States · NIH-11004959

• Investigating the role of mural stem cells in brain development and hemorrhage in preterm infants

  This study is looking at how special cells in the brain help form blood vessels, especially in preterm babies who might have bleeding in the brain, to better understand their development and find new ways to help them.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10991694

• Wearable tech to track blood loss during childbirth

  A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.

  NIH research Washington University · Saint Louis, United States · NIH-11627926

• SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers

  This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11625633

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.