Impact of brain fluid volume on neurological outcomes in preterm infants with bleeding
Official title: Effects of ventricular volume and cerebral connectivity on neurological outcomes in preterm intraventricular hemorrhage
Funded at Washington University · NIH-11004959 · Data updated 2026-11-12
This study looks at how the amount of fluid in the brains of very preterm babies with brain bleeding affects their development and thinking skills, with the hope of finding ways to help them grow and learn better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 1, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $536,899 |
| NIH project number | 5R01NS124767-04 |
| Project ID | NIH-11004959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are very preterm infants born at or before 32 weeks of gestation who have experienced intraventricular hemorrhage.
✕Less likely to help
Patients who are not preterm or who do not have a history of brain bleeding may not benefit from this research.
What this research studies
This research investigates how the volume of fluid in the brain affects neurological outcomes in very preterm infants who experience bleeding in the brain. By using advanced imaging techniques, the study aims to understand the relationship between brain structure and function, particularly focusing on how changes in brain fluid volume can influence connectivity in the brain. The goal is to identify critical factors that contribute to cognitive deficits and disabilities in these vulnerable infants, ultimately improving treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment options for preterm infants suffering from brain injuries, potentially reducing long-term neurological disabilities.
How similar studies have gone: Previous research has shown promising results in understanding the neurological impacts of brain fluid volume in similar populations, indicating that this approach has potential for significant insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Smyser, Christopher Daniel — Washington University
- Study coordinator: Smyser, Christopher Daniel
Related research
Other NIH-funded projects on the same topics.
-
Brain fluid buildup and brain wiring after bleeding in very premature babies
Sees if larger fluid-filled spaces and changes in brain connections are linked to thinking and movement problems in very premature babies who had brain bleeding.
-
Safety of combining erythropoietin and melatonin for very preterm infants with brain bleeds
A Johns Hopkins team is testing a combination of melatonin and erythropoietin to help very preterm babies who have intraventricular hemorrhage avoid longer-term brain problems.
-
Understanding epilepsy risk in very preterm infants with brain hemorrhage
This study is looking at how very premature babies who have serious bleeding in the brain might develop epilepsy and other developmental challenges, and it aims to find early signs that could help doctors identify these risks so they can provide better care and support for these little ones.
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Investigating the role of mural stem cells in brain development and hemorrhage in preterm infants
This study is looking at how special cells in the brain help form blood vessels, especially in preterm babies who might have bleeding in the brain, to better understand their development and find new ways to help them.
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Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
-
SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.