Investigating the role of mural stem cells in brain development and hemorrhage in preterm infants
Mural stem cells in normal development and germinal matrix hemorrhage in the preterm human brain
This study is looking at how special cells in the brain help form blood vessels, especially in preterm babies who might have bleeding in the brain, to better understand their development and find new ways to help them.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10991694 on NIH RePORTER |
What this research studies
This research focuses on understanding how mural stem cells contribute to the development of blood vessels in the brain, particularly in preterm infants who are at risk for brain hemorrhages. By using advanced techniques like Fluorescence Activated Cell Sorting and single cell RNA sequencing, the study aims to identify different stages and types of mural cells during brain development. The findings could help clarify the mechanisms behind brain injuries in preterm infants and potentially lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are preterm infants who are at risk for developing brain hemorrhages.
Not a fit: Patients who are not preterm or do not have a history of brain hemorrhage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for brain hemorrhages in preterm infants.
How similar studies have performed: While there has been significant research on adult brain blood vessels, this approach focusing on developing human brain vasculature is relatively novel and untested.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Crouch, Elizabeth Erin — University of California, San Francisco
- Study coordinator: Crouch, Elizabeth Erin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.