Understanding epilepsy risk in very preterm infants with brain hemorrhage
Official title: Epilepsy and Neurodevelopmental Risk Stratification in Very Preterm Infants with Intraventricular Hemorrhage
Funded at Washington University · NIH-11080978 · Data updated 2026-11-12
This study is looking at how very premature babies who have serious bleeding in the brain might develop epilepsy and other developmental challenges, and it aims to find early signs that could help doctors identify these risks so they can provide better care and support for these little ones.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $232,870 |
| NIH project number | 5K23NS136762-02 |
| Project ID | NIH-11080978 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are very preterm infants (born at or before 32 weeks of gestation) who have experienced high-grade intraventricular hemorrhage.
✕Less likely to help
Patients who are not very preterm or do not have a history of intraventricular hemorrhage may not benefit from this research.
What this research studies
This research investigates how very preterm infants who experience high-grade intraventricular hemorrhage (IVH) may develop epilepsy and neurodevelopmental issues. By using advanced techniques like high-density EEG to monitor brain network changes, the study aims to identify early biomarkers that can predict these outcomes. The goal is to gather data during a critical period of brain development, which could lead to better screening and intervention strategies for at-risk infants. This approach focuses on understanding the brain's connectivity to improve future treatments.
Why it matters
Potential benefit: If successful, this research could lead to early identification and intervention strategies that significantly reduce the risk of epilepsy and improve developmental outcomes for affected infants.
How similar studies have gone: Previous research has shown promise in using brain network assessments to predict epilepsy in high-risk populations, indicating that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Triplett, Regina — Washington University
- Study coordinator: Triplett, Regina
Related research
Other NIH-funded projects on the same topics.
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Brain fluid buildup and brain wiring after bleeding in very premature babies
Sees if larger fluid-filled spaces and changes in brain connections are linked to thinking and movement problems in very premature babies who had brain bleeding.
-
Safety of combining erythropoietin and melatonin for very preterm infants with brain bleeds
A Johns Hopkins team is testing a combination of melatonin and erythropoietin to help very preterm babies who have intraventricular hemorrhage avoid longer-term brain problems.
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Impact of brain fluid volume on neurological outcomes in preterm infants with bleeding
This study looks at how the amount of fluid in the brains of very preterm babies with brain bleeding affects their development and thinking skills, with the hope of finding ways to help them grow and learn better.
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Investigating the role of mural stem cells in brain development and hemorrhage in preterm infants
This study is looking at how special cells in the brain help form blood vessels, especially in preterm babies who might have bleeding in the brain, to better understand their development and find new ways to help them.
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Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
-
SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.