Identifying risk factors for psychosis during menopause

PREMAP - Predictors and Risk Evaluation for Menopause-Associated Psychosis

NIH-funded research Yale University · NIH-10954254

This study is looking at how hormonal changes during menopause might lead some women to experience psychosis, and it’s inviting women who have had their first episode of psychosis during this time to share their health histories so we can better understand how to help those who might be at risk.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionYale University NIH-funded
Lab location1 site (New Haven, United States)
Project IDNIH-10954254 on NIH RePORTER

What this research studies

This research investigates the development of psychosis in women during the menopause transition, a time when hormonal changes may increase vulnerability to mental health issues. The study aims to recruit individuals who have experienced a first episode of psychosis during this period and compare their medical, reproductive, psychiatric, and family histories to those of women who developed depression instead. By understanding these risk factors, the research seeks to provide insights into prevention and treatment strategies for affected women.

Who could benefit from this research

Good fit: Ideal candidates for this research are women experiencing menopause who have developed psychosis or depression during this transition.

Not a fit: Patients who are not experiencing menopause or who have not developed psychosis or depression during this period may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved identification and management of psychosis in women undergoing menopause.

How similar studies have performed: While research on psychosis in relation to menopause is limited, similar studies have successfully identified risk factors for other mental health conditions during hormonal transitions.

Where this research is happening

New Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions attenuated psychosis syndrome
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.