Identifying risk factors for psychosis during menopause
Official title: PREMAP - Predictors and Risk Evaluation for Menopause-Associated Psychosis
Funded at Yale University · NIH-10954254 · Data updated 2026-11-12
This study is looking at how hormonal changes during menopause might lead some women to experience psychosis, and it’s inviting women who have had their first episode of psychosis during this time to share their health histories so we can better understand how to help those who might be at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 18, 2023 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $693,568 |
| NIH project number | 5R01MH131768-03 |
| Project ID | NIH-10954254 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing menopause who have developed psychosis or depression during this transition.
✕Less likely to help
Patients who are not experiencing menopause or who have not developed psychosis or depression during this period may not benefit from this research.
What this research studies
This research investigates the development of psychosis in women during the menopause transition, a time when hormonal changes may increase vulnerability to mental health issues. The study aims to recruit individuals who have experienced a first episode of psychosis during this period and compare their medical, reproductive, psychiatric, and family histories to those of women who developed depression instead. By understanding these risk factors, the research seeks to provide insights into prevention and treatment strategies for affected women.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and management of psychosis in women undergoing menopause.
How similar studies have gone: While research on psychosis in relation to menopause is limited, similar studies have successfully identified risk factors for other mental health conditions during hormonal transitions.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Powers, Albert R — Yale University
- Study coordinator: Powers, Albert R
Related research
Other NIH-funded projects on the same topics.
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PREMAP: Predictors of Menopause-Related Psychosis
A study to understand what factors predict psychosis that can occur during menopause, with a focus on women going through that transition.
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Risk factors for psychosis during the menopause transition
This project looks for medical, reproductive, psychiatric, and family-history signs that might predict new psychosis in women going through the menopause transition.
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Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
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Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
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A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
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Understanding how vaginal tissue changes after menopause affect reproductive health
A research team is studying why the vaginal lining changes after menopause and how this affects health, with potential solutions to improve comfort and reduce infection risk for postmenopausal women.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.