Investigating how mitochondrial dysfunction affects airway inflammation in obese asthma
Official title: Parkin in mitochondrial dysfunction and airway inflammation of obese asthma
Funded at National Jewish Health · NIH-10898829 · Data updated 2026-11-12
This study is looking at how problems with tiny energy factories in our cells, called mitochondria, can make asthma worse for people who are both obese and have asthma, and it hopes to find new ways to help them breathe better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | September 16, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $712,997 |
| NIH project number | 5R01AI152504-05 |
| Project ID | NIH-10898829 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are obese and have been diagnosed with asthma.
✕Less likely to help
Patients who are not obese or do not have asthma may not benefit from this research.
What this research studies
This research aims to understand the role of mitochondrial dysfunction in exacerbating airway inflammation specifically in obese individuals with asthma. It focuses on the mechanisms by which increased levels of Parkin, an E3 ubiquitin ligase, contribute to inflammation in the airways of obese asthmatics. By analyzing samples from patients, the study will explore how mitochondrial DNA and fatty acids influence asthma severity and response to treatment. The findings could lead to new therapeutic strategies for managing asthma in obese patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for obese asthma patients, enhancing their quality of life and asthma control.
How similar studies have gone: Other research has shown promising results in understanding the role of mitochondrial dysfunction in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Chu, Hong W — National Jewish Health
- Study coordinator: Chu, Hong W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.