Sepsis patient care guided by Ugandan-wide immune profiling
Official title: Multidimensional and longitudinal immune profiling of sepsis in Uganda
Funded at Columbia University Health Sciences · NIH-11573596 · Data updated 2026-11-12
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 12, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $130,125 |
| NIH project number | 3R01AI184997-03S1 |
| Project ID | NIH-11573596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with sepsis in Uganda participating in the multicenter cohort.
✕Less likely to help
Results may be less directly applicable to patients who do not have similar immune or infection profiles as the study population.
What this research studies
Researchers will collect blood samples from sepsis patients in Uganda and use multiple modern tests to understand each person’s immune response. They will build and test a scoring framework called MoSS to categorize patients by their host-response patterns and guide treatment choices. The plan includes comparing findings with U.S. and European cohorts to see if these immune patterns are broadly applicable. This work aims to translate complex biological data into practical ways to tailor therapies for sepsis in diverse populations.
Why it matters
Potential benefit: If successful, doctors may be able to tailor sepsis treatments to a patient’s immune profile, potentially improving survival and recovery.
How similar studies have gone: Previous multi-omic approaches have shown promise in stratifying sepsis patients, with this project expanding validation across settings.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Cummings, Matthew John — Columbia University Health Sciences
- Study coordinator: Cummings, Matthew John
Related research
Other NIH-funded projects on the same topics.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
-
Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Role of MMP3 in heart dysfunction during sepsis
This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
-
Endothelial inflammation memory after sepsis and pneumonia
A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.