Noninvasive bedside monitoring of brain blood flow after brain bleed (aSAH)
Official title: Noninvasive monitoring of cerebrovascular regulation in subarachnoid hemorrhage.
Funded at University of South Florida · NIH-11237140 · Data updated 2026-11-12
Aims to use a small, noninvasive device to monitor brain blood flow in patients with aneurysmal subarachnoid hemorrhage to help predict complications and guide treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | December 12, 2023 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $509,279 |
| NIH project number | 5R01NS135077-03 |
| Project ID | NIH-11237140 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with aneurysmal subarachnoid hemorrhage admitted to the hospital who are eligible for bedside monitoring.
✕Less likely to help
Patients without aSAH or those not undergoing bedside monitoring may not benefit from this specific approach.
What this research studies
If you or a loved one has aSAH, this project tests a new handheld optical tool that tracks how blood moves in the brain after the bleed. The researchers will use continuous bedside measurements to look for early signs of delayed cerebral ischemia and to see how well current treatments keep brain tissue perfused. By comparing these measurements with patient outcomes, they hope to identify patterns that signal when more aggressive care is needed. The study plans to enroll patients in a hospital setting and analyze data to improve prediction and management of DCI.
Why it matters
Potential benefit: If successful, this approach could help doctors detect dangerous brain blood flow changes earlier and tailor treatments to prevent brain injury.
How similar studies have gone: Previous work shows promise for noninvasive brain monitoring, but this study aims to demonstrate bedside PR-DCS effectiveness in predicting DCI.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Mokin, Maxim — University of South Florida
- Study coordinator: Mokin, Maxim
Related research
Other NIH-funded projects on the same topics.
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-
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This project is creating a blood test to spot which people who had a brain aneurysm bleed are likely to develop delayed brain injury in the days after the bleed.
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Biomarkers to Fine-Tune Intrathecal Nicardipine for Brain Bleeding-Related Stroke
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Adropin as a shield for the brain after a brain hemorrhage
A potential treatment with adropin is being studied to protect brain cells after a subarachnoid hemorrhage and reduce stroke-like damage.
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Manganese-based compound as a potential therapy for subarachnoid hemorrhage
A new manganese porphyrin-based drug is being explored as a possible treatment to reduce brain injury after a subarachnoid hemorrhage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.