Understanding how stroke increases the risk of blood clots in veins
Mechanisms for Deep Vein Thrombosis following Stroke
This study is looking at how certain white blood cells and a specific protein might cause blood clots in older adults who have had a stroke, with the goal of finding safer ways to prevent these clots from forming.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project ID | NIH-10906785 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind deep vein thrombosis (DVT) that can occur after a stroke, particularly focusing on the role of neutrophils and a specific protein called integrin α9. The study aims to understand how these neutrophils contribute to the formation of blood clots in patients who have experienced a stroke, especially in older adults. By exploring these mechanisms, the researchers hope to identify new and safer treatments to prevent DVT in high-risk patients. The approach includes both animal models and human studies to gather comprehensive data on this issue.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have recently experienced an acute ischemic stroke.
Not a fit: Patients who have not had a stroke or are not at risk for deep vein thrombosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of dangerous blood clots in stroke patients.
How similar studies have performed: Previous studies have shown promising results in understanding the role of neutrophils in blood clot formation, suggesting that this research builds on established findings.
Where this research is happening
Shreveport, United States
- Louisiana State Univ Hsc Shreveport — Shreveport, United States (Active)
Researchers
- Principal investigator: Dhanesha, Nirav — Louisiana State Univ Hsc Shreveport
- Study coordinator: Dhanesha, Nirav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.