Understanding how stroke increases the risk of blood clots in veins
Official title: Mechanisms for Deep Vein Thrombosis following Stroke
Funded at Louisiana State Univ Hsc Shreveport · NIH-10906785 · Data updated 2026-11-12
This study is looking at how certain white blood cells and a specific protein might cause blood clots in older adults who have had a stroke, with the goal of finding safer ways to prevent these clots from forming.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | August 20, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $433,881 |
| NIH project number | 5R01HL158546-03 |
| Project ID | NIH-10906785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have recently experienced an acute ischemic stroke.
✕Less likely to help
Patients who have not had a stroke or are not at risk for deep vein thrombosis may not benefit from this research.
What this research studies
This research investigates the mechanisms behind deep vein thrombosis (DVT) that can occur after a stroke, particularly focusing on the role of neutrophils and a specific protein called integrin α9. The study aims to understand how these neutrophils contribute to the formation of blood clots in patients who have experienced a stroke, especially in older adults. By exploring these mechanisms, the researchers hope to identify new and safer treatments to prevent DVT in high-risk patients. The approach includes both animal models and human studies to gather comprehensive data on this issue.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of dangerous blood clots in stroke patients.
How similar studies have gone: Previous studies have shown promising results in understanding the role of neutrophils in blood clot formation, suggesting that this research builds on established findings.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Dhanesha, Nirav — Louisiana State Univ Hsc Shreveport
- Study coordinator: Dhanesha, Nirav
Related research
Other NIH-funded projects on the same topics.
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Neutrophil integrin α9 and blood clots after stroke in aging
This project looks at how a molecule on white blood cells called neutrophil integrin α9 might cause dangerous vein clots after a stroke, especially in older adults.
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Understanding how DVT forms and heals to prevent vein scarring
This NIH grant supports a physician-scientist to study why deep vein clots form and how vein walls get scarred, with the goal of improving long-term outcomes for patients who develop DVT.
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Oscillatory blood flow and vein valve health to prevent clots
Aimed at understanding how the natural rhythmic blood flow in leg veins protects against clots and whether restoring that flow can prevent dangerous vein clots in hospitalized patients.
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Local anti-inflammatory therapy to help dissolve clots and prevent vein damage in DVT
Aims to test a local anti-inflammatory treatment to help resolve deep vein clots and reduce long-term vein problems in people with DVT.
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Metabolic tricks to prevent and heal dangerous blood clots in the leg
A study at a university aims to see if shifting how certain blood cells use energy can stop leg clots from forming and help bodies clear clots faster, reducing future complications.
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Stopping long-term leg damage after deep vein clots by giving anti-inflammatory medicine around the vein
This will try giving anti-inflammatory medicine around the affected vein to lower the chance of long-term swelling, pain, and skin problems after a deep vein clot (DVT).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.