Stopping long-term leg damage after deep vein clots by giving anti-inflammatory medicine around the vein
Preventing Post-Thrombotic Syndrome after Deep Vein Thrombosis with Perivascular Anti-Inflammatory Agent Delivery
['FUNDING_SBIR_2'] · MERCATOR MEDSYSTEMS, INC. · NIH-11194237
This will try giving anti-inflammatory medicine around the affected vein to lower the chance of long-term swelling, pain, and skin problems after a deep vein clot (DVT).
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MERCATOR MEDSYSTEMS, INC. (nih funded) |
| Locations | 1 site (San Leandro, UNITED STATES) |
| Trial ID | NIH-11194237 on ClinicalTrials.gov |
What this research studies
After a deep vein clot, inflammation can scar and stiffen the vein wall and lead to chronic leg problems called post-thrombotic syndrome (PTS). This project is developing a way to deliver anti-inflammatory drug directly around the vein (perivascular delivery) to block that damaging inflammation. The team plans laboratory and early-stage translational work to optimize the delivery method and drug dosing and move toward use in patients with recent DVT, especially larger proximal clots. The goal is to stop the vein scarring process that current clot-removal methods do not address.
Who could benefit from this research
Good fit: People with a recent deep vein thrombosis—especially larger, proximal clots such as iliofemoral DVT—would be the most likely candidates.
Not a fit: Patients with long-established post-thrombotic scarring, very distal clots, or those who present late after symptom onset may not benefit from this approach.
Why it matters
Potential benefit: If it works, this approach could reduce chronic swelling, pain, skin changes, and ulcers after DVT and improve patients' quality of life.
How similar studies have performed: Prior trials that focused on removing clots have not lowered PTS, so locally delivering anti-inflammatory therapy to prevent vein scarring is a relatively new and unproven approach in patients.
Where this research is happening
San Leandro, UNITED STATES
- MERCATOR MEDSYSTEMS, INC. — San Leandro, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEWARD, KIRK — MERCATOR MEDSYSTEMS, INC.
- Study coordinator: SEWARD, KIRK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.