Mapping how ventilator use can harm lungs
Cellular and molecular mapping of ventilator-induced lung injury
This study is looking at how using a ventilator can affect the lungs of people who develop acute respiratory distress syndrome (ARDS), with the goal of finding better treatments for those who experience lung injury from high-pressure ventilation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11047671 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular changes that occur in the lungs of patients who develop acute respiratory distress syndrome (ARDS) due to ventilator use. By using a specialized system to ventilate human lungs at different pressures, researchers aim to understand how high-pressure ventilation can lead to lung injury. The study will analyze lung tissue samples to identify specific cellular responses and molecular profiles associated with this injury, providing insights into the mechanisms behind ARDS. This approach may help in developing targeted treatments for patients affected by ventilator-induced lung injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who are on mechanical ventilation and at risk for developing acute respiratory distress syndrome.
Not a fit: Patients who are not on mechanical ventilation or do not have acute respiratory distress syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from ARDS, potentially reducing morbidity and mortality associated with ventilator use.
How similar studies have performed: Previous research has shown promise in understanding ventilator-induced lung injury, but this study employs a novel approach to directly assess cellular responses in human lungs.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Desai, Tushar Jasubhai — Stanford University
- Study coordinator: Desai, Tushar Jasubhai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.