Mapping how ventilator use can harm lungs
Official title: Cellular and molecular mapping of ventilator-induced lung injury
Funded at Stanford University · NIH-11047671 · Data updated 2026-11-12
This study is looking at how using a ventilator can affect the lungs of people who develop acute respiratory distress syndrome (ARDS), with the goal of finding better treatments for those who experience lung injury from high-pressure ventilation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | March 4, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $599,888 |
| NIH project number | 5R01HL170601-02 |
| Project ID | NIH-11047671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are on mechanical ventilation and at risk for developing acute respiratory distress syndrome.
✕Less likely to help
Patients who are not on mechanical ventilation or do not have acute respiratory distress syndrome may not benefit from this research.
What this research studies
This research investigates the cellular and molecular changes that occur in the lungs of patients who develop acute respiratory distress syndrome (ARDS) due to ventilator use. By using a specialized system to ventilate human lungs at different pressures, researchers aim to understand how high-pressure ventilation can lead to lung injury. The study will analyze lung tissue samples to identify specific cellular responses and molecular profiles associated with this injury, providing insights into the mechanisms behind ARDS. This approach may help in developing targeted treatments for patients affected by ventilator-induced lung injury.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from ARDS, potentially reducing morbidity and mortality associated with ventilator use.
How similar studies have gone: Previous research has shown promise in understanding ventilator-induced lung injury, but this study employs a novel approach to directly assess cellular responses in human lungs.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Desai, Tushar Jasubhai — Stanford University
- Study coordinator: Desai, Tushar Jasubhai
Related research
Other NIH-funded projects on the same topics.
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How high-pressure ventilators can damage human lungs
Researchers will compare high- versus low-pressure ventilation on donated human lungs to learn which cells and molecules get hurt in people with respiratory failure.
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Protecting the lung lining during ventilator-related injury
This work develops ways to keep the lung's barrier intact in people with ARDS who need mechanical ventilation.
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Understanding how to protect lung tissue during mechanical ventilation in patients with severe respiratory distress
This study is looking at how using a ventilator can sometimes hurt the lungs of people with acute respiratory distress syndrome (ARDS), and it aims to find the best ways to help their lungs heal while still providing the support they need.
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Finding ways to prevent lung injury caused by ventilators in patients with severe respiratory issues.
This study is looking at ways to make breathing machines safer for people with acute respiratory distress syndrome (ARDS) by creating a system that helps doctors adjust the machines to better fit each patient's needs, which could lead to better recovery.
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How different ventilator settings affect lung energy during gallbladder surgery
This study tests whether two ventilator modes (VCV and PRVC) deliver different amounts of energy to the lungs in adults undergoing laparoscopic gallbladder removal.
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Height measurement methods to guide ventilator settings in ARDS
We’re testing whether more precise height measurements change how researchers set lung-protective tidal volumes in adults with ARDS who are on a ventilator.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.