How high-pressure ventilators can damage human lungs
Cellular and molecular mapping of ventilator-induced lung injury
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11324205
Researchers will compare high- versus low-pressure ventilation on donated human lungs to learn which cells and molecules get hurt in people with respiratory failure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11324205 on ClinicalTrials.gov |
What this research studies
This project uses donated human lungs perfused and ventilated outside the body to mimic what happens during mechanical ventilation. For each donor pair, one lung will get high-pressure ventilation and the other low-pressure ventilation so each person serves as their own control. Scientists will profile individual cells using single-cell RNA sequencing and map proteins and RNA in intact tissue to link molecular changes with where damage happens. Some experiments will add high oxygen, higher PEEP, or bacteria to better mirror conditions seen in critically ill patients.
Who could benefit from this research
Good fit: Results are most relevant to people who have or are at high risk for ARDS and to patients who are currently or expected to be mechanically ventilated.
Not a fit: People without respiratory failure or who will never require mechanical ventilation are unlikely to receive direct benefit from this research.
Why it matters
Potential benefit: If successful, the work could identify targets to prevent or treat ventilator-associated lung injury and help people with ARDS recover better.
How similar studies have performed: Prior animal and some human-tissue studies have suggested mechanisms of ventilator-induced injury, but this detailed single-cell and spatial mapping in human lungs is largely novel.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DESAI, TUSHAR JASUBHAI — STANFORD UNIVERSITY
- Study coordinator: DESAI, TUSHAR JASUBHAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome