Understanding how to protect lung tissue during mechanical ventilation in patients with severe respiratory distress
Preserving Epithelial Barrier Integrity in Ventilator-Induced Lung Injury
This study is looking at how using a ventilator can sometimes hurt the lungs of people with acute respiratory distress syndrome (ARDS), and it aims to find the best ways to help their lungs heal while still providing the support they need.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11077693 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind ventilator-induced lung injury (VILI) in patients suffering from acute respiratory distress syndrome (ARDS). It aims to identify optimal ventilation strategies that balance lung injury and repair, as current treatments are limited. By studying the timing of ventilatory cycles and their effects on lung tissue integrity, the research seeks to develop better management approaches for ARDS patients. The methodology includes both in vivo and in vitro experiments to understand the dynamics of lung repair and injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with acute respiratory distress syndrome requiring mechanical ventilation.
Not a fit: Patients with mild respiratory issues or those not requiring mechanical ventilation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved ventilation strategies that significantly reduce mortality rates in ARDS patients.
How similar studies have performed: Previous research has shown promising results in understanding lung injury mechanisms, indicating potential for success in this area.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Bates, Jason Ht — University of Vermont & St Agric College
- Study coordinator: Bates, Jason Ht
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.