Sponsor or institution
Clinical trials and research at Virginia Polytechnic Inst and St Univ
As of November 12, 2026, Find a Trial lists 274 NIH-funded research projects at this institution, with $123.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 274NIH research projects
NIH-funded research (newest 40 of 274)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Histotripsy + immune boost to fight osteosarcoma
A new treatment idea combines a precise non-surgical ultrasound method with an immune-boosting compound to help fight bone cancer in people and dogs.
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Understanding how front-thalamus connections affect thinking and behavior in schizophrenia
Researchers are studying how the prefrontal cortex and mediodorsal thalamus work together to support thinking, memory, and behavior in schizophrenia, with the goal of finding new ways to help people who have cognitive difficulties.
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Data-driven hormonal modeling of vaginal tissue changes across a woman’s life
A data-driven, physics-informed computer model will map how hormones drive vaginal tissue remodeling across puberty, reproductive life, and menopause to help predict risks and tailor therapies.
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Supporting flood recovery in rural areas through health data and knowledge sharing
Aimed at people in rural Appalachian regions affected by inland flooding, this project will use health data and rapid information sharing to inform recovery and future planning.
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Adaptation of PATH-Pain for Dementia Family Caregivers Living with Persistent Pain and Negative Emotions
Aimed at helping dementia family caregivers who live with ongoing pain and negative feelings by adapting a pain-management program to fit their caregiving needs.
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Genomic surveillance for antimicrobial resistance in aquaculture pathogens
This project aims to build a DNA-based tracking system to spot antibiotic resistance in bacteria that affect fish farms, helping protect animal health and food safety.
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Healthy Brain and Child Development in the US: a large, multi-site study of early life factors
A large nationwide study follows mothers and their babies from birth to age 10 to understand how genes and early life experiences shape brain development.
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New ways to add radiolabeled CF3 groups for PET tracers
Researchers are developing versatile methods to attach radiolabeled CF3 groups to molecules so PET tracers can better visualize biological processes in the body.
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AI-designed antimicrobial peptide to fight drug-resistant infections
A research team is using artificial intelligence to optimize tiny protein-like molecules (peptides) to kill tough bacteria that often resist last-resort antibiotics.
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Deciphering how a brain cell pH helper influences glioma growth
A study is exploring whether a brain cell pH regulator (Slc4a4) affects the growth and blood vessel changes of malignant glioma to identify new angles for treatment.
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How SAMD9L gene changes harm blood stem cells in children
This project looks at how changes in the SAMD9L gene damage blood-forming stem cells in children with inherited bone marrow failure and pediatric myelodysplastic syndrome.
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Handheld, image-guided histotripsy to precisely ablate thyroid tumors
A tiny, handheld device uses sound waves to precisely destroy thyroid tumors without harming nearby nerves and vessels.
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New balance training to prevent falls in older adults
A new, low-cost balance training program for people 65 and older aims to reduce the chance of falls by improving fast recovery after a trip.
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Genetically programmable gels to deliver biologics in the GI tract
A novel gel material engineered to stick to specific parts of the GI tract and protect biologic medicines, then release them on demand.
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Hidden microproteins in the Aedes mosquito
Researchers are exploring tiny, often overlooked proteins in Aedes aegypti that could reveal new ways to prevent mosquito-borne diseases.
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Competitive microbial interactions in biofilm infections and how they shape pathogen adaptation
This grant explores how different microbes interact in chronic wound infections to understand which organisms drive disease and how they respond to treatment.
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Pulse-echo speed-of-sound imaging for breast cancer care
Aadvanced ultrasound method measures how fast sound travels through breast tissue to better detect and characterize breast cancer.
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How viruses decide cell fate and cell death in people like you
Scientists are studying how viruses and our cells talk to each other to decide whether a cell should stay alive or die, which can affect how infections spread and how our bodies respond.
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Nitroxoline: a dual-action antibiotic for drug-resistant gonorrhea and chlamydia
Researchers are testing an old antibiotic, nitroxoline, in an oral therapy aimed at treating both drug-resistant gonorrhea and chlamydia in people.
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Viral tricks that disrupt heart cell connections in myocarditis
This grant looks at how a common cold virus (adenovirus) may mess with the heart’s electrical signals and could lead to dangerous arrhythmias in people with myocarditis.
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Direct dopamine recording in people performing working memory tasks
Scientists are testing how dopamine signals in the brain relate to working memory in people with epilepsy, using real-time brain recordings during memory tasks.
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BMP3’s Role in Pulmonary Hypertension
A study exploring how BMP3 signals in the lungs might protect blood vessels in people with pulmonary hypertension.
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Understanding how electronic polarization affects biomolecule folding and drug binding
Scientists are exploring how tiny electric effects inside molecules influence the way they fold and interact with potential drugs, with a focus on diseases like Alzheimer’s and certain cancers.
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How giant viruses have shaped the evolution of plants, animals, and algae
A scientist-led project will study giant DNA viruses that infect algae and other eukaryotes to understand how these viruses and their hosts have influenced each other over millions of years.
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Dystonia-specific brain signaling pattern in cerebellum
Aims to identify a characteristic pattern of nerve cell activity in the cerebellum that is linked to dystonia, with studies in mice and potential implications for people with the condition.
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Protist oxygen sensing in human disease
A scientist is studying how certain single-celled organisms detect oxygen and how this might relate to diseases in humans.
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The Transdermal Bioreactor: a skin patch that builds patient’s own therapeutic cells at the bedside
A skin patch called the Transdermal Bioreactor aims to create and deliver therapeutic cells inside your body right at your bedside.
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Flow-informed therapy for glioblastoma
A new approach uses patient MRI data and 3D modeling to map how fluid flows in and around brain tumors to guide targeted therapies for glioblastoma patients.
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Endothelial ROS in Exercise and Muscle Metabolism
This grant explores how reactive oxygen species produced by blood vessel cells during exercise help muscles adapt and stay healthy.
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Stress hormones and herpes viruses: how nerve signals trigger recurrences
A science project will study how stress hormones trigger reactivation of herpes viruses (HSV1 and HSV2) in different nerve cells, with the goal of improving understanding and future treatments for recurrent outbreaks.
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Forecasting how new tobacco taxes could affect what people buy and use
Aims to predict how four different new tobacco tax ideas might change what people buy and how they smoke, considering income and education levels.
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Regulation of 22q11 Genes in Brain Development and Function
A study in mouse models of 22q11.2 deletion looks at how brain circuits develop and function, with potential relevance to people with 22q11.2 Deletion Syndrome.
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Using genomics to improve care for cryptococcal meningitis in people with HIV
This project builds lab and training capacity to use genomic and immune testing to help adults with HIV who get cryptococcal meningitis.
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Building genomic expertise to combat cryptococcal meningitis
This program helps local labs and scientists in Africa use genome and immune testing to improve diagnosis and treatment for adults with cryptococcal meningitis.
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Copper enzymes that use oxygen in unique ways to power metabolism
Aerospace-friendly-sounding title aside, this grant explores how copper-containing enzymes use oxygen to drive important chemical reactions in cells and what role aromatic amino acids play in those processes.
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Antivirulence pills to block harmful bacteria’s “sticky” tools (T4P) to fight antibiotic resistance
A small study tests new medicines that disarm bacteria instead of killing them, aiming to help people by reducing infections from drug-resistant bacteria.
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RWELL Trial: Safer Drinking Water for Appalachian Families
A study tests a low-cost, household water treatment approach to improve health for people in rural Appalachia who rely on private wells.
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How age changes immune cell responses after a head injury
Researchers are comparing how immune cells from younger versus older bodies react after a traumatic brain injury to learn why age alters recovery.
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Understanding a Brucella gene pathway that drives disease
Researchers are studying a specific Brucella gene pathway to see how it helps the bacteria survive inside immune cells and cause disease in animals and people.
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Understanding and engineering protein degradation by the ubiquitin-proteasome system
Researchers aim to better understand and gently modify how cells recycle proteins to help conditions linked to protein mismanagement in humans and plants.
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