Understanding how blood clots in deep veins can lead to long-term complications
Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis
This study is looking into how deep vein thrombosis (DVT) affects healing and can lead to long-term problems like post-thrombotic syndrome (PTS), with the goal of finding better treatments for people dealing with these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11044095 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind deep vein thrombosis (DVT) and its complications, particularly post-thrombotic syndrome (PTS), which can cause lasting disability. The project aims to explore the roles of inflammation and fibrosis during the healing process of DVT, which may either aid in tissue repair or contribute to further damage. By utilizing both basic and translational research methods, the study seeks to uncover new insights that could improve treatment strategies for patients suffering from DVT and PTS. The research is conducted by Dr. Khanh Nguyen at the Portland VA Medical Center, supported by a team of experienced mentors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced deep vein thrombosis or are at risk of developing post-thrombotic syndrome.
Not a fit: Patients who have not experienced DVT or those with other unrelated vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent long-term complications from DVT, enhancing the quality of life for affected patients.
How similar studies have performed: Previous studies have shown promise in understanding DVT and its complications, but this research aims to explore novel mechanisms that have not been extensively tested.
Where this research is happening
Portland, United States
- Portland VA Medical Center — Portland, United States (Active)
Researchers
- Principal investigator: Nguyen, Khanh P. — Portland VA Medical Center
- Study coordinator: Nguyen, Khanh P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.