Understanding how blood clots in deep veins can lead to long-term complications

Who could benefit from this research

What this research studies

This research investigates the mechanisms behind deep vein thrombosis (DVT) and its complications, particularly post-thrombotic syndrome (PTS), which can cause lasting disability. The project aims to explore the roles of inflammation and fibrosis during the healing process of DVT, which may either aid in tissue repair or contribute to further damage. By utilizing both basic and translational research methods, the study seeks to uncover new insights that could improve treatment strategies for patients suffering from DVT and PTS. The research is conducted by Dr. Khanh Nguyen at the Portland VA Medical Center, supported by a team of experienced mentors.

Why it matters

Where this research is happening

• Portland VA Medical Center
  Portland, United States Active

Researchers

• Principal investigator: Nguyen, Khanh P. — Portland VA Medical Center
• Study coordinator: Nguyen, Khanh P.

Related research

Other NIH-funded projects on the same topics.

• Understanding how DVT forms and heals to prevent vein scarring

  This NIH grant supports a physician-scientist to study why deep vein clots form and how vein walls get scarred, with the goal of improving long-term outcomes for patients who develop DVT.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11522579

• Oscillatory blood flow and vein valve health to prevent clots

  Aimed at understanding how the natural rhythmic blood flow in leg veins protects against clots and whether restoring that flow can prevent dangerous vein clots in hospitalized patients.

  NIH research Washington University · Saint Louis, United States · NIH-11448544

• Local anti-inflammatory therapy to help dissolve clots and prevent vein damage in DVT

  Aims to test a local anti-inflammatory treatment to help resolve deep vein clots and reduce long-term vein problems in people with DVT.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11446647

• Neutrophil integrin α9 and blood clots after stroke in aging

  This project looks at how a molecule on white blood cells called neutrophil integrin α9 might cause dangerous vein clots after a stroke, especially in older adults.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11396538

• Metabolic tricks to prevent and heal dangerous blood clots in the leg

  A study at a university aims to see if shifting how certain blood cells use energy can stop leg clots from forming and help bodies clear clots faster, reducing future complications.

  NIH research University of Iowa · Iowa City, United States · NIH-11375490

• Stopping long-term leg damage after deep vein clots by giving anti-inflammatory medicine around the vein

  This will try giving anti-inflammatory medicine around the affected vein to lower the chance of long-term swelling, pain, and skin problems after a deep vein clot (DVT).

  NIH research Mercator Medsystems, INC. · San Leandro, UNITED STATES · NIH-11194237

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.