Investigating how specific proteins affect kidney disease
Official title: Role of the Factor H Related Proteins in Kidney Disease
Funded at University of Colorado Denver · NIH-11058515 · Data updated 2026-11-12
This study is looking at how certain proteins in the body affect kidney diseases, especially those caused by the immune system, to help find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $481,125 |
| NIH project number | 5R01DK138960-02 |
| Project ID | NIH-11058515 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune kidney diseases or those affected by conditions related to complement system dysregulation.
✕Less likely to help
Patients with kidney diseases unrelated to the complement system or those who do not have autoimmune conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of Factor H-related proteins in kidney diseases, particularly autoimmune glomerulonephritis. It aims to explore how these proteins regulate the complement system, which is crucial for immune responses in the kidneys. By using animal models and monoclonal antibodies, the study will investigate how these proteins interact with complement activation and inflammation in kidney tissues. This could lead to new insights into the mechanisms of kidney disease and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for various kidney diseases by targeting specific proteins involved in immune regulation.
How similar studies have gone: Previous research has shown that targeting components of the complement system can lead to significant advancements in treating autoimmune diseases, suggesting a promising avenue for this investigation.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Thurman, Joshua M — University of Colorado Denver
- Study coordinator: Thurman, Joshua M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.