Investigating how a specific protein affects abdominal aortic aneurysms
Official title: The Role of Platelet-Derived Transforming Growth Factor Beta in Abdominal Aortic Aneurysm
Funded at University of Cincinnati · NIH-10995575 · Data updated 2026-11-12
This study is looking at how a specific protein called TGFβ affects the growth of abdominal aortic aneurysms (AAAs) to help find new ways to treat this condition for people who have it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,960 |
| NIH project number | 1F31HL175976-01 |
| Project ID | NIH-10995575 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with abdominal aortic aneurysms, particularly those who are being monitored for aneurysm growth.
✕Less likely to help
Patients who do not have abdominal aortic aneurysms or those who have already undergone surgical repair may not benefit from this research.
What this research studies
This research focuses on understanding the role of platelet-derived transforming growth factor beta (TGFβ) in the development and progression of abdominal aortic aneurysms (AAAs). It aims to uncover the molecular mechanisms that influence AAA initiation and growth, which could lead to new therapeutic strategies. The study will involve analyzing how TGFβ interacts with various cells and signaling pathways in the aorta, particularly in patients with AAAs. By improving our understanding of these processes, the research seeks to identify potential targets for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent the progression of abdominal aortic aneurysms, potentially saving lives.
How similar studies have gone: Previous studies have shown that targeting TGFβ can influence aneurysm progression in animal models, indicating a promising area of investigation.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Spuzzillo, Anthony — University of Cincinnati
- Study coordinator: Spuzzillo, Anthony
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.