Understanding heart disease risk in patients on hemodialysis
Official title: Elucidating the Biology of Cardiovascular Risk in Hemodialysis Patients Using Proteomics
Funded at Ut Southwestern Medical Center · NIH-10836013 · Data updated 2026-11-12
This study is looking at why people with severe kidney disease who are on dialysis often have heart problems, and it will check blood samples to find out which proteins might be linked to heart health, with the goal of creating better ways to prevent and treat heart disease for these patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 15, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $732,468 |
| NIH project number | 5R01HL153499-04 |
| Project ID | NIH-10836013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with end-stage renal disease who are currently receiving hemodialysis treatment.
✕Less likely to help
Patients who are not on hemodialysis or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the high rates of cardiovascular disease among patients with end-stage renal disease who are undergoing hemodialysis. It aims to identify the biological factors that contribute to these risks by analyzing protein levels in the blood, which may serve as indicators for heart disease. The study utilizes a cutting-edge technique called SOMAscan to measure thousands of proteins from small blood samples, allowing for a detailed understanding of how these proteins relate to cardiovascular health. By uncovering these relationships, the research seeks to develop personalized strategies for preventing and treating heart disease in this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and preventing cardiovascular disease in hemodialysis patients.
How similar studies have gone: Previous research has shown promise in using protein biomarkers to assess cardiovascular risk, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Dubin, Ruth — Ut Southwestern Medical Center
- Study coordinator: Dubin, Ruth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.