Improving sample handling for T cell lymphoma testing
Official title: Optimizing pre-analytic sample handling for high throughput TCR sequencing in cutaneous T cell lymphoma
Funded at Brigham and Women's Hospital · NIH-10856922 · Data updated 2026-11-12
This study is looking to improve how skin biopsy samples are handled for people with cutaneous T cell lymphoma, so that the DNA and important markers stay safe and accurate, helping doctors make better diagnoses and treatment choices.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $384,912 |
| NIH project number | 5U01CA253190-05 |
| Project ID | NIH-10856922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cutaneous T cell lymphoma who are undergoing skin biopsy procedures.
✕Less likely to help
Patients with other types of lymphoma or those not requiring skin biopsies may not benefit from this research.
What this research studies
This research focuses on enhancing the accuracy of high throughput sequencing (HTS) for patients with cutaneous T cell lymphoma (CTCL) by optimizing how skin biopsy samples are processed. It aims to identify the best methods for transporting and preserving these samples to ensure that DNA and other important biological markers remain intact. The study will evaluate different fixatives and storage conditions to minimize DNA degradation, which can lead to incorrect diagnoses and treatment decisions. Ultimately, the research will test these optimized procedures in real clinical trial settings to ensure their effectiveness.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better treatment options for patients with cutaneous T cell lymphoma.
How similar studies have gone: Previous research has shown that optimizing sample handling can significantly improve diagnostic accuracy in similar contexts, indicating a promising approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Clark, Rachael Ann — Brigham and Women's Hospital
- Study coordinator: Clark, Rachael Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.