Understanding how gene regulation affects cutaneous T cell lymphoma
Epigenetic Regulation of Differentially Expressed Genes in Cutaneous T Cell Lymphoma
This study is looking at how changes in DNA can affect a type of skin cancer called cutaneous T cell lymphoma, especially a severe form known as Sezary syndrome, to help find better ways to diagnose and treat it, and patients can help us learn more about how these changes might impact their treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-11030755 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic changes, particularly DNA methylation, in cutaneous T cell lymphoma, focusing on Sezary syndrome, a severe form of this cancer. By examining how these changes lead to abnormal gene expression, the study aims to identify potential biomarkers for diagnosis and new therapeutic targets. The research utilizes genomic profiling techniques to analyze the gene expression of malignant T cells, providing insights into the mechanisms of oncogenesis. Patients may contribute to understanding how these epigenetic alterations can influence treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cutaneous T cell lymphoma, particularly those with Sezary syndrome.
Not a fit: Patients with other types of cancers or those without a diagnosis of cutaneous T cell lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with cutaneous T cell lymphoma.
How similar studies have performed: Previous research has shown promising results in understanding epigenetic regulation in various cancers, suggesting potential for success in this area as well.
Where this research is happening
San Diego, United States
- VA San Diego Healthcare System — San Diego, United States (Active)
Researchers
- Principal investigator: Wong, Henry Keung — VA San Diego Healthcare System
- Study coordinator: Wong, Henry Keung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.