Understanding how IL-15 affects T-cell lymphoma in the skin
Official title: The Role of IL-15 in Cutaneous T-cell Lymphoma Progression
Funded at Thomas Jefferson University · NIH-11138570 · Data updated 2026-11-12
This research explores how a specific signal, called IL-15, helps T-cell lymphoma cells move to and grow in the skin, aiming to find new ways to help patients with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 20, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $356,850 |
| NIH project number | 5R01CA266592-03 |
| Project ID | NIH-11138570 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is for patients with Cutaneous T-cell Lymphoma (CTCL) who are seeking new insights into their disease and future treatment options.
✕Less likely to help
Patients without Cutaneous T-cell Lymphoma (CTCL) would not directly benefit from this specific research.
What this research studies
Cutaneous T-cell Lymphoma (CTCL) is a skin cancer where T-cells gather in the skin, causing difficult-to-treat lesions and impacting quality of life. We want to understand why these cancer cells prefer the skin and how they progress there. Our work focuses on a signal called interleukin-15 (IL-15), which we've found to be elevated in patients and seems to drive the cancer cells to the skin. By understanding this process, we hope to uncover new ways to stop the disease from spreading in the skin.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent CTCL cells from localizing to the skin, potentially improving disease management and quality of life for patients.
How similar studies have gone: Previous findings from this team have shown that IL-15 overexpression can induce a CTCL-like condition in models, suggesting this pathway is a promising area for further investigation.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Mishra, Anjali — Thomas Jefferson University
- Study coordinator: Mishra, Anjali
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.