Improving heart health in veterans with heart failure and kidney disease
Official title: Improving Outcomes in Veterans with Heart Failure and Chronic Kidney Disease
Funded at U.s. Dept/vets Affairs Medical Center · NIH-11232298 · Data updated 2026-11-12
This study is looking at how small doses of certain heart and blood pressure medications can help veterans with heart failure and kidney problems feel better, while also keeping their kidneys safe, and it aims to find out which patients might benefit the most from these treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | U.s. Dept/vets Affairs Medical Center NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | April 1, 2019 |
| Project end | September 30, 2024 |
| Funding year | 2025 |
| NIH project number | 5I01HX002422-05 |
| Project ID | NIH-11232298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with heart failure and chronic kidney disease who are currently receiving or may benefit from ACE inhibitors or angiotensin receptor blockers.
✕Less likely to help
Patients without heart failure or chronic kidney disease may not receive any benefit from this research.
What this research studies
This research investigates how low doses of ACE inhibitors and angiotensin receptor blockers can improve health outcomes for veterans suffering from heart failure and chronic kidney disease. The study aims to determine the safety and effectiveness of these medications while minimizing the risk of kidney injury. By utilizing a large dataset from the VA and the American Heart Association, researchers will develop a machine-learning algorithm to identify which patients are most likely to benefit from these treatments based on their individual health profiles.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment options for veterans with heart failure and chronic kidney disease.
How similar studies have gone: Previous research has shown that ACE inhibitors and ARBs can reduce mortality in heart failure patients with chronic kidney disease, indicating a foundation for this study's approach.
Where this research is happening
-
U.s. Dept/vets Affairs Medical Center
Washington, United States Active
Researchers
- Principal investigator: Ahmed, Ali — U.s. Dept/vets Affairs Medical Center
- Study coordinator: Ahmed, Ali
Related research
Other NIH-funded projects on the same topics.
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Improving heart health in veterans with heart failure and kidney disease
This study is looking at how small doses of certain heart medications can help veterans with heart failure and kidney problems feel better, while also making sure their kidneys stay safe, and it will use smart technology to find out which patients might benefit the most from these treatments.
-
Understanding heart failure in patients with chronic kidney disease
This study is looking at how chronic kidney disease might lead to heart problems, specifically heart failure with preserved ejection fraction, by examining changes in certain substances in the body, and it's aimed at helping people with kidney disease better understand and manage their heart health.
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Improving health outcomes for veterans with heart failure and kidney disease
This study is looking at how small doses of certain heart and blood pressure medications can help veterans with heart failure and kidney problems feel better, by figuring out who might benefit the most from them based on their health needs.
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Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
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This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.