Understanding heart failure in patients with chronic kidney disease
Official title: Pathogenesis of Heart Failure with Preserved Ejection Fraction in Chronic Kidney Disease
Funded at Northwestern University at Chicago · NIH-10884380 · Data updated 2026-11-12
This study is looking at how chronic kidney disease might lead to heart problems, specifically heart failure with preserved ejection fraction, by examining changes in certain substances in the body, and it's aimed at helping people with kidney disease better understand and manage their heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $189,120 |
| NIH project number | 5K23HL150236-04 |
| Project ID | NIH-10884380 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease who are also experiencing symptoms of heart failure.
✕Less likely to help
Patients without chronic kidney disease or those with heart failure not related to kidney issues may not benefit from this research.
What this research studies
This research investigates how chronic kidney disease (CKD) contributes to heart failure with preserved ejection fraction (HFpEF). The study aims to identify specific metabolic changes in CKD patients that may lead to HFpEF, using data from a large epidemiological cohort. By analyzing circulating metabolites, the research seeks to uncover CKD-specific mechanisms that could explain the high prevalence of HFpEF in these patients. Ultimately, the goal is to improve understanding and treatment options for heart failure in the context of kidney disease.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies for heart failure in patients with chronic kidney disease.
How similar studies have gone: Previous research has indicated that metabolic changes play a significant role in heart failure, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Mehta, Rupal — Northwestern University at Chicago
- Study coordinator: Mehta, Rupal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.