Imaging the Pulmonary Circulation to Personalize ARDS Care
Official title: Imaging the Pulmonary Circulation to Aid Personalized Management of Acute Respiratory Distress Syndrome
Funded at Massachusetts General Hospital · NIH-11385479 · Data updated 2026-11-12
A patient-focused look at using advanced imaging to understand lung blood flow in ARDS so doctors can tailor treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 29, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $796,497 |
| NIH project number | 5R01HL171199-03 |
| Project ID | NIH-11385479 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults hospitalized with Acute Respiratory Distress Syndrome (ARDS) who can undergo CT imaging.
✕Less likely to help
Patients who cannot undergo CT imaging or have contraindications to contrast agents may not benefit.
What this research studies
This grant aims to develop non-invasive imaging methods to visualize how blood moves through the lungs in ARDS patients. By using dynamic contrast-enhanced CT and dual-energy CT, researchers plan to map where blood flow is too high or low and how this relates to lung injury. The goal is to link imaging findings to how ARDS progresses and to guide more personalized treatment decisions. The work will involve patients with adult ARDS and will build on existing imaging techniques to capture lung perfusion in real time. Results could lead to better strategies to protect the lungs and improve outcomes.
Why it matters
Potential benefit: If successful, patients with ARDS could receive more precise treatments guided by real-time imaging of their lung blood flow.
How similar studies have gone: Prior research shows promise for perfusion imaging in the lung, but this project seeks to translate it into personalized ARDS management.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Cereda, Maurizio Franco — Massachusetts General Hospital
- Study coordinator: Cereda, Maurizio Franco
Related research
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This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.