Sponsor or institution
Clinical trials and research at Oregon Health & Science University
As of November 12, 2026, Find a Trial lists 915 NIH-funded research projects at this institution, with $552.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 915NIH research projects
NIH-funded research (newest 40 of 915)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding how a protein affects nerve cell movement in Alzheimer's disease
This study is looking at how a protein called APP affects the growth and movement of nerve cells, which is important for understanding Alzheimer's disease, and it aims to find out how problems with this protein might lead to nerve cell damage.
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Understanding how the bone marrow environment drives AML resistance
A large NIH-funded project at Oregon Health & Science University is studying how the body’s own cell surroundings help acute myeloid leukemia become resistant to treatment, with potential paths to better therapies for patients.
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Improving Safety at Work with a Low-Resource mHealth Program in Malaysia (and beyond)
A low-cost mobile health program to improve safety culture in Malaysian workplaces, with plans to adapt the approach for U.S. workers in high-risk industries.
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Oregon Healthy Workplace Initiative for Better Health
A multi-site effort aims to improve the health and safety of workers by coordinating research, tools, and interventions across workplaces.
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Understanding how AML cells become resistant to therapy over time
This project looks at why acute myeloid leukemia stops responding to treatment and how to design better drug combinations to prevent relapse.
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Mechanisms and Countermeasures for Ultra-Potent Synthetic Opioid Overdose
A small, focused NIH grant aims to understand why ultra-potent synthetic opioids cause severe overdose and to explore potential countermeasures to keep people safe.
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Oregon Spina Bifida Registry Project - Comp B
This grant supports building and refining a national registry to track care practices and health outcomes for people living with spina bifida to improve care and quality of life.
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PRaCTICe: A Rural and Frontier Clinical Trials Innovation Center
A nationwide network is creating easier, community-led clinical trials in rural and frontier areas to bring more trials to patients where they live.
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A low-cost mobile health approach to improve workplace safety in Malaysia with lessons for U.S. workers
A scalable, smartphone-based safety program being developed in Malaysia aims to reduce injuries in high-risk industries and show how it could be adapted for U.S. workers.
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Understanding how donor T cells could cure HIV after stem cell transplant
This grant looks at how immune cells from a donor might help cure HIV in people who have had a life-saving stem cell transplant.
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Turning data into action to improve occupational health in Oregon
A people-focused project uses health data to improve how workers in Oregon stay safe and healthy at work.
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Nanobody-Based Diagnostics for Tuberculosis
Aims to develop fast, multi-antigen TB tests using tiny antibody fragments to improve diagnosis for people with suspected TB, including those with HIV.
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Blocking CFTR in the cervix to prevent conception without hormones
A non-hormonal approach aims to stop sperm from entering the uterus by making cervical mucus too thick for sperm, potentially offering a new contraception option.
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Targeted blocking of FXI to prevent thromboinflammation in bacterial sepsis
Aims to see if inhibiting FXI can reduce blood clotting and inflammation during serious bacterial infections like anthrax, to improve outcomes.
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Profiling tRNA Diversity One Cell at a Time
A new method will map how tRNA shapes differ from cell to cell in brain-like cells and organoids, aiming to shed light on neurodevelopment and neurodegenerative diseases.
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SUMO regulation of ribosome production in human cells
A physician-facing project exploring how a chemical modification system called SUMO helps build ribosomes in human cells, which are essential for growth and health.
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Trajectories of secondary outcomes in CTN trials
Researchers at BU and collaborators will analyze existing CTN trial data to find patterns in mental health and substance use outcomes over time.
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Modern BSL-3 Biocontainment Facility at OHSU for High-Containment Research
A modern BSL-3 lab facility at Oregon Health & Science University will enable researchers to safely study dangerous pathogens and advance infectious disease science.
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Community Vital Signs: finding undiagnosed high blood pressure in Nigeria
A plan to screen adults in Nigeria for high blood pressure and connect those who need care to local clinics using community programs and digital tools.
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How HIV-related gut damage affects the gut and brain health
This project studies how damage in the gut from HIV/SIV infection may lead to brain inflammation and cognitive issues, even when HIV is suppressed by treatment.
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Persistence of HIV-specific B cells after early ART in Thai children
This grant studies how HIV-specific B cells behave in children who started ART very early after birth.
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Understanding how early BPA exposure could lead to liver cancer
This project looks at whether exposure to the chemical BPA during development can cause liver cancer later in life, using animal models to understand the risks.
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Oral bacteria vesicles steering immune signals in autoimmune disease
A study to see if tiny packages from mouth bacteria can change immune signals and possibly help conditions like Behçet’s syndrome.
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Fluorescence-guided nerve preservation during skull-base surgery
A new imaging approach uses special dyes that glow during surgery to help protect cranial nerves in skull-base operations.
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Understanding RUNX1-related preleukemia in teens and how to stop it
This research looks at why some teens with RUNX1 gene changes are at higher risk for leukemia and how we might prevent it.
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GPR39-based treatment approach for aging-related brain vascular dementia
A new drug-style compound that activates GPR39 in the brain is being studied to help people with vascular dementia linked to aging.
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Neuroinflammation and vascular cognitive impairment in aging
This grant looks at how metabolic risk factors in midlife affect aging-related brain changes and memory problems, using mouse models and human brain findings to understand why vascular and inflammatory processes contribute to dementia.
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Repairing severe lower leg and muscle injuries
This project tests a nanoscale scaffold plus exercise approach to help people with complex lower-leg bone and muscle injuries heal better.
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How early-life BPA exposure may lead to liver cancer
Researchers are looking at whether exposure to the common chemical BPA before birth or in early life can cause changes that lead to liver cancer.
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AAV gene therapy for Alport syndrome
A gene therapy approach using AAV vectors is studied to help people with Alport syndrome by restoring the missing collagen in the kidneys.
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New drug target for toxoplasmosis and a selective inhibitor
A new drug target in Toxoplasma gondii is being explored, with an aim to create a selective inhibitor to treat toxoplasmosis.
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Role of VEGF signaling in healthy hearing and aging-related cochlear thinning
This grant studies how blood vessel signals affect hearing as people age, with the goal of protecting hearing and brain health in older adults.
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Robo receptor pathways to block nerve loss in autism-related neurodegeneration
Aims to find molecular steps that cause nerve fiber and synapse loss in autism-related brain changes and explore how to stop this damage.
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Prenatal mindfulness and inflammatory pathways to support mom and baby health
A study from Oregon Health & Science University will explore how mindfulness during pregnancy might influence inflammatory signals and improve emotional well-being for mothers and healthy development for their children.
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Ferroptosis in brain cells and blood vessels in dementia due to Alzheimer's and vascular disease
This NIH grant explores how a specific cell death process called ferroptosis in brain support cells and blood vessels may contribute to dementia linked to Alzheimer's and vascular disease, with the goal of uncovering new ways to protect brain health.
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New anti-leishmanial tambjamines to treat visceral leishmaniasis
Aims to develop improved tambjamine compounds to treat dangerous visceral leishmaniasis, focusing on safer, more effective oral therapies for people affected by this neglected disease.
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AI-powered eye scans to detect glaucoma earlier and more accurately
A new project uses advanced eye imaging and artificial intelligence to measure a tiny retina layer more precisely, helping detect glaucoma earlier for patients.
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Understanding jaw joint changes after corrective jaw surgery
This grant studies how jaw mechanics and behavior before and after corrective jaw surgery relate to changes in the jaw joint and its tissues.
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Pericyte signaling in diabetic stroke-related cognitive problems
A patient-facing study exploring how blood vessel cells and inflammation after stroke interact in people with diabetes to influence cognitive decline and dementia.
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How astrocytes influence brain remodeling in autism
A scientist at Oregon Health & Science University is studying how support cells in the brain called astrocytes affect the reshaping of neural connections in autism.
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