Sponsor or institution
Clinical trials and research at Univ of Massachusetts Med Sch Worcester
As of November 12, 2026, Find a Trial lists 715 NIH-funded research projects at this institution, with $404.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 715NIH research projects
NIH-funded research (newest 40 of 715)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding HIV-1 Env shapes to boost immune attack against infected cells
Aimed at helping people living with HIV, this project explores how specific HIV-1 envelope structures attract or resist immune attack so future therapies could better help the body clear hidden virus.
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Reprogramming metabolism to power alternative fat-burning modes
A new project will explore how fat cells burn calories in different ways to help combat obesity.
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Silencing an Extra Chromosome to Help Down Syndrome and Related Conditions
A patient-friendly plan to use a gene-based approach to quiet an extra chromosome in cells and a mouse model to reduce disease-related effects in Down syndrome and other chromosomal imbalance disorders.
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Gut microbes and brain function in autism
Researchers are exploring how gut bacteria may influence brain signals and behavior in autism, using worm models to uncover possible links that could someday inform human therapies.
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Chlamydia and gonorrhea interaction: how host interferons influence co-infection
A human-health focused project looks at how the body’s interferon signals during chlamydia infection affect the way gonorrhea behaves, with potential implications for people vulnerable to both infections.
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Conquering High Blood Pressure in Vietnamese Cities
A program to adapt and test a proven plan for lowering high blood pressure in urban Vietnam using a mobile health platform and integrated care approach.
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Predicting how genetic variants affect function and disease traits
Aims to build computer models that predict how genetic differences influence biology and disease traits, using large genomic datasets.
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NCDC Project 001 at UMass Medical School
This project helps UMass clinical teams work together and share data so patient-focused studies can run more smoothly.
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Understanding cell problems in Down syndrome and Down syndrome–associated Alzheimer’s
This project uses stem cells made from people with Down syndrome and a genetic switch to turn off the extra chromosome so researchers can pinpoint how the extra chromosome causes blood, brain, and Alzheimer‑related changes.
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ARISe Center for Rural Vaccination at UMass Chan Medical School
A center at UMass Chan Medical School is being created to study and improve vaccination in rural areas across New England.
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Physical Activity Policy Network to Boost Community Design for More Active Living
A national network is being re-established to support communities in designing policies and plans that make walking and biking easier and safer for people in everyday life.
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How the RTS,S malaria vaccine protects children in Kenya
This project looks at whether the RTS,S malaria vaccine helps children in high-malaria areas of Kenya develop the kinds of antibodies and T cells that prevent malaria.
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Nationwide rollout of an HIV prevention program for Bahamian youth
A team is expanding an evidence-based HIV prevention program for Bahamian students and families to reach more schools and ensure teachers implement it well.
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A newly discovered regulator that controls gut inflammation
This work looks at a newly found gene regulator that keeps immune cells in the gut from causing harmful inflammation, which could help people with inflammatory bowel conditions.
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IgA-producing plasma cells in the spleen: how gut microbes shape systemic immunity
This NIH grant explores how gut microbes influence special IgA-producing cells in the spleen to help keep both gut and body immunity balanced.
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How losing SIRT3 harms mitochondria in TB infections
Researchers are studying how weakening of a mitochondrial regulator called SIRT3 may contribute to worse cellular energy and stress in tuberculosis.
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Time-dependent membrane proteins in circadian brain cells
A research project will map how membrane proteins in brain clock neurons change over time and may reveal targets to support healthy sleep, metabolism, and behavior.
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AAV-based gene silencing for a rare brain disease in kids and adults
A gene-silencing therapy using an AAV9-delivered amiRNA targets TUBB4A mutations to slow or stop the progression of H-ABC, a serious brain disease that affects movement.
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Understanding FUS-related ALS/FTD and how to fix it
This NIH grant explores how problems with a key RNA-binding protein called FUS contribute to ALS and related diseases, using human cells and mouse models to uncover potential treatments.
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Causes and Effects of Somatic Mutations in Parkinson’s Disease
This project looks at how random DNA changes in brain cells might contribute to Parkinson’s disease, aiming to understand why neurons die as people age.
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DECIDE-AF: a shared decision tool in your health portal to help prevent strokes in atrial fibrillation
A patient-friendly tool in your electronic health record helps you and your doctor choose the right way to prevent strokes if you have atrial fibrillation.
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Endosomal RNA/DNA Sensors in Brain Disease
A researcher team at a major medical school is studying how endosomal nucleic acid sensors in brain immune cells may drive inflammation in diseases like Alzheimer's and other neurodegenerative conditions.
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Botulinum toxin blocks nerve signals to immune cells to treat hidradenitis suppurativa
This NIH grant tests a new approach to hidradenitis suppurativa by using botulinum toxin to interrupt nerve signals that may drive skin inflammation in patients.
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Camk2b loss fuels pancreatic cancer spread and immune suppression
A new NIH grant seeks to understand why losing CAMK2B in pancreatic cancer makes the cancer spread more and suppresses immune responses, using advanced mouse models.
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Nonhuman Primate Reagent Resource for Translational Immunology
A national resource is being renewed to provide validated reagents tailored for nonhuman primates to support preclinical research in infectious diseases, transplantation, and immunotherapy.
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Understanding how gut cells recognize disease-causing microbes
A research project will study how intestinal cells in humans identify microbes that are actively causing disease, with potential to inform better treatments for inflammatory bowel diseases.
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Metformin Readiness for Aortic Valve Stenosis
A plan to prepare for a patient-focused trial of metformin to slow aortic valve stenosis in adults, using insights from human valves and biology.
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Molecular functions of key BAF subunits in chromatin remodeling
This grant explores how DPF1, DPF3, and PHF10 help brain cells control which genes are turned on or off, which can affect neurodevelopment and related conditions.
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Genetically encoded inhibitors to study retrotransposon roles in brain development
A new approach uses specially designed intrabodies to block individual enzymes of retrotransposons in neurons, starting with Copia in fruit flies, to understand how these elements influence brain development and aging.
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How B and T cells diversify their antibodies and stay healthy by managing DNA repair
Aims to understand how a key DNA repair enzyme, APE1, is reduced during immune development to let antibody diversity happen while keeping cells safe.
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Joint optimization of SPECT imaging components for targeted alpha therapy
A small study at UMass Worcester is testing a smarter way to image tumors during targeted alpha therapy to help doctors see where treatment is working.
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New genetic clues and cells to understand ALS
Researchers are studying how new mutations that occur after conception might contribute to ALS, with a focus on spinal cord motor neurons and cells from ALS patients.
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Bringing in New Glow Substances for Better Bioluminescence
This grant aims to create new glow chemicals and compatible enzymes to improve bioluminescent imaging in animals for drug discovery and research.
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MARCO’s role in controlling immune alarms in infection
A study to understand how a key macrophage receptor called MARCO helps manage the body’s warning signals during bacterial infections and severe inflammatory responses.
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How BAF chromatin remodelers move DNA to influence gene activity
This NIH-funded project studies how BAF chromatin remodeling proteins change the way DNA is packaged to affect gene activity, with implications for cancer and neurodevelopmental disorders.
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Understanding how DNA signals and proteins control gene access in human cells
Aims to map how regions of the genome and the proteins that bind them control which genes are turned on or off in human cells, using advanced computer methods and single-cell data.
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Impact of hospice drug policies on costs, use, and access in older adults
This grant looks at how changes in hospice drug payments affect what medications are used, how much is spent, and how easily older adults can access the drugs they need.
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Prevention Research Center at UMass Chan: turning community ideas into healthier places
A Center at UMass Chan will help local health departments and community groups put proven ideas for safer, more activity-friendly environments into action, especially to help people stay active and healthier.
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Lifestyle change program study for people using GLP-1 medications
A patient-focused study will test a digital lifestyle-change program called Noom to help people using GLP-1 therapies improve activity, eating habits, and overall health.
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Helping doctors prescribe blood thinners for atrial fibrillation
A new electronic alert for doctors aims to help people with atrial fibrillation get guideline-recommended blood thinners.
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