Hypnotic Resistance in Insomnia: How Common It Is and What Increases Risk
Official title: Hypnotic Resistance: Definitions, Prevalence, and Risk Factors
Funded at Mayo Clinic Rochester · NIH-11445263 · Data updated 2026-11-12
This NIH grant explores why some people with insomnia don’t respond to hypnotic meds and what factors, including genetics, predict this resistance.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 15, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $242,100 |
| NIH project number | 1R21HL181601-01A1 |
| Project ID | NIH-11445263 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with chronic insomnia who have been treated with hypnotics and have or are at risk of treatment resistance.
✕Less likely to help
Patients who achieve complete response to hypnotics or who do not meet TRI definitions may not see direct benefit.
What this research studies
The project uses real-world patient data from Mayo Clinic sources to define and measure how often treatment-resistant insomnia occurs. It will review electronic health records to refine definitions and confirm them by chart review. Researchers will look for clinical and demographic risk factors and build a predictive model to identify who is at higher risk for TRI. They will also investigate the genetic underpinnings of TRI using genome-wide studies and meta-analysis to see how genetics may influence treatment response.
Why it matters
Potential benefit: If successful, clinicians could better identify patients at risk for TRI and tailor treatments or prevention strategies accordingly.
How similar studies have gone: Prior work suggests a complex mix of clinical, demographic, and genetic factors in treatment response, but TRI definitions and predictive models are still being refined.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Coombes, Brandon — Mayo Clinic Rochester
- Study coordinator: Coombes, Brandon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.