Genomic factors shaping lung cancer risk in Native Hawaiians and Pacific Islanders
Official title: Characterizing genomic risk factors of lung cancers in Native Hawaiians
Funded at University of Hawaii at Manoa · NIH-11375087 · Data updated 2026-11-12
This NIH grant focuses on understanding why Native Hawaiians, Pacific Islanders, and African Americans have higher lung cancer risk and poorer outcomes by studying tumor DNA and related molecular patterns.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | September 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $530,426 |
| NIH project number | 5U54HG013243-04 |
| Project ID | NIH-11375087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with lung cancer who are Native Hawaiian, Pacific Islander, or African American, and whose tumor samples or data can contribute to comparative genomic analyses.
✕Less likely to help
Patients outside NH/PI/AA groups or those without tumor samples may not directly benefit from this study.
What this research studies
Researchers at the University of Hawaii at Manoa will study genomic differences in lung tumors from NH/PI and AA patients to uncover molecular factors linked to higher risk and worse survival. The project will compare tumor DNA and methylation patterns to those in more represented populations to identify race-specific drivers of lung cancer. The work aims to fill gaps where NH patients have been underrepresented in major genomic projects, potentially guiding tailored prevention and treatment strategies. The study involves analyzing tumor samples and associated data to map distinct molecular profiles across populations. Outcomes could inform precision medicine approaches for NH/PI and AA communities affected by lung cancer.
Why it matters
Potential benefit: The research could lead to more accurate risk assessment and personalized treatments for NH/PI and AA patients with lung cancer.
How similar studies have gone: Previous genomic studies have shown racial disparities in lung cancer drivers, but NH/PI groups have been underrepresented, making this work particularly novel and important.
Where this research is happening
-
University of Hawaii at Manoa
Honolulu, United States Active
Researchers
- Principal investigator: Deng, Youping — University of Hawaii at Manoa
- Study coordinator: Deng, Youping
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.