Sponsor or institution
Clinical trials and research at University of Hawaii at Manoa
As of November 12, 2026, Find a Trial lists 215 NIH-funded research projects at this institution, with $142.7 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 215NIH research projects
NIH-funded research (newest 40 of 215)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Using laser technology to improve anal cancer screening for HIV-positive patients
This study is testing a new, gentle way to check for anal dysplasia in people with HIV, using a special laser technique that could make screenings easier and more comfortable than the usual methods.
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Predicting microbial virulence from genome sequences with language models
A research project aims to use advanced AI models trained on genetic sequences to predict how dangerous different microbes might be, helping doctors and public health teams respond more quickly.
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Early sensory development and language in infants/toddlers at risk for autism
A family-friendly study exploring how early sensory responses relate to language development in young children who have siblings with autism.
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Ola Hawaii Research Capacity Core: strengthening health research resources
A national-level core facility at the University of Hawaii at Manoa helps researchers do health-related studies by providing high-quality data, biostatistics, clinical research support, and community engagement resources.
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Personalized nutrition tools using mobile and image-based methods
This grant supports creating and validating mobile and image-based dietary tools to better connect dietary data with cancer and chronic disease outcomes for people across diverse populations.
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PILI ‘Āina: Gardened foods, culturally rooted health for Native Hawaiian adults
A community program helps overweight Native Hawaiian adults eat healthier, lose weight, and lower heart-disease risk through culturally tailored education and at-home gardening.
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Hawaii NCORP: Expanding access to NCI cancer trials for Hawaii residents
A nationwide cancer research program in Hawaii aims to give Hawaii residents better access to NCI-sponsored cancer trials and care, with a focus on representing the state’s diverse population.
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Anti-inflammatory signaling of a key protein in heart attack recovery
A study in people who have had a heart attack is exploring how a macrophage protein called Tristetraprolin may reduce inflammation and help protect heart tissue.
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Ola HAWAII: Advancing Minority Health and Health Disparities in Hawaii
A nationwide NIH center in Hawaii aims to boost basic, clinical, and behavioral health research to reduce health disparities among minority communities.
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Savvy Caregiver Peer Program to help American Indian dementia caregivers
A caregiver-focused program in American Indian communities adds peer-led, culturally respectful support to help family members caring for someone with dementia.
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Hawaii–Pacific breast imaging registry to improve detection for Asian and Native Hawaiian women
Creating a regional mammography registry to find imaging signs that help catch invasive and advanced breast cancer earlier in Native Hawaiian, Asian, and Pacific Islander women.
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Long-term study of NAFLD progression and gut bacteria in diverse groups
We’re following people over time to see how the gut microbiome and diet relate to fatty liver disease progression in diverse racial/ethnic groups.
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Understanding why DCIS becomes invasive breast cancer in Asian American and Native Hawaiian/Pacific Islander groups
A research project aims to identify biological factors and risk patterns that predict when early-stage DCIS may progress to invasive breast cancer, with a focus on AANHPI populations.
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Maui Wildfire Exposure in Children: Long-Term Health, Development, and Education
This grant funds a long-term study of how the Maui wildfires affect children’s health, development, and schooling, following kids who were exposed and comparing them with unexposed peers.
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Measuring the Impact of a Native Hawaiian Birth Program on Maternal Health
A community-based study in Hawaiʻi will look at how a culturally grounded birth program affects maternal health and birth outcomes for Native Hawaiian and Pacific Islander women.
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Aina-Based Engagement and Social Epigenomic Pathways to Metabolic Health for Native Hawaiian Youth
A Native Hawaiian youth program combines Indigenous knowledge with modern science to understand and improve blood sugar health and inflammation through community-led farming and gut microbiome changes.
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How Treponema pallidum behaves in human infection (single-cell RNA clues)
A small, targeted study will map how the syphilis-causing bacteria act inside human infections using new single-cell RNA methods.
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Biomarkers to predict and improve immunotherapy response in lung cancer
This grant aims to find gene-based markers that predict which NSCLC patients will benefit from immunotherapy and to uncover ways to make treatment work better for those who don’t respond.
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Population health and health system resiliency after Maui's wildfire disaster
A study in Maui will follow how healthcare and communities respond to a major wildfire, with the goal of improving access to care and resilience for residents and responders.
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Maui wildfire exposure: health and resilience cohort
A long-term study of Maui residents to understand how wildfires affect health and well-being and to help communities recover.
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Prenatal PFAS and Microplastics: How early exposure shapes a child’s brain
A first-trimester pregnancy study in Hawaii will look at how common pollutants PFAS and microplastics together might affect baby brain development and health after birth.
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Long-term safety and effectiveness of Dengvaxia in the Philippines
This project watches how Dengvaxia behaves in real life in Filipino children over many years to understand safety and how well it protects against dengue.
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How source and message style affect young adults’ responses to vaping education
We’re testing how the messenger (trusted expert vs. peer) and the way a message is presented (one-sided vs. two-sided) influence how 18–24-year-old vapers and non-vapers respond to e-cigarette education.
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Targeted DNA insertion in human cells using a piggyBac-based platform
A new platform aims to safely and precisely insert large pieces of DNA into human cells without relying on risky DNA breaks, with potential for gene therapies and research.
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New immunotherapy combo for hard-to-treat triple-negative breast cancer
Aims to test a combination immunotherapy with JNK inhibitors to improve treatment for people with triple-negative breast cancer.
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Bacteria hitchhiking on fungal highways to spread in environments and bodies
Aims to understand how bacteria move along fungal filaments and carry molecules, which could affect infections and distribution in people and buildings.
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Legionella in soil: how climate and soil biology affect its danger
This project looks at how soil conditions and climate influence Legionella bacteria and their amoeba hosts, to understand the risk of environmentally caused pneumonia.
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Vaginal Microbiome and Social Factors in Preterm Birth among Hawaiʻi Women
A study in Hawaiʻi women looks at how the vaginal microbiome and social factors relate to the risk of delivering a baby early.
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What keeps our microbiome steady during infections
This grant looks at how our body’s microbial communities stay stable when a pathogen hits, which could help keep infections milder and protect health.
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InSTAR Core: A Center for Arthropod Models and Microbiome Research
A core facility at the University of Hawaii at Manoa will support research using arthropods to study how microbiomes influence host development, health, and disease vectors, with potential benefits for human health.
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MGAL Core: a centralized hub for microbial genomics and metabolomics at UH Mānoa
A centralized lab core at UH Mānoa helps researchers study how the microbes around us relate to human health using advanced sequencing, metabolomics, and microbial biobanking.
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Microscopy Imaging Center core to support microbiome research
A core imaging facility in Hawaii provides advanced microscopes and training to help researchers study microbes, their hosts, and environments.
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Administrative Core for the Integrative Center for Environmental Microbiomes and Human Health
This grant funds the administrative backbone of a center focused on how environmental microbes affect human health, helping researchers collaborate and stay organized so projects can move forward.
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Integrative Center for Environmental Microbiomes and Human Health
A large center aims to understand how environmental microbiomes affect human health and develop new tools to study microbes in different environments.
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Gene network that links weighty brain signals to repetitive behavior in ketosis
This grant looks at how a ketogenic diet might change brain signals to reduce repetitive behaviors in an animal model.
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Pono Health Legacy Study in Native Hawaiians, Pacific Islanders, and Asian Americans
A long-term study in Hawai‘i will follow Native Hawaiians, Pacific Islanders, and Asian Americans to understand how genes, environment, and behavior influence heart, lung, and metabolic health.
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Culturally grounded ENDS prevention for rural Hawaiian youth
A culturally tailored program will be created and tested to help rural Hawaiian youth avoid using electronic nicotine products.
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Ola HAWAII: Improving Health for Communities
This program aims to improve health and reduce health differences for communities in Hawaii that face significant health challenges.
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Community Engagement for Health Equity in Hawaii's Underserved Communities
A program to strengthen trusted community partnerships in Hawaii to improve health outcomes for Native Hawaiians, Pacific Islanders, and other underserved groups.
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Investigator Development Core to Grow a Diverse Health Disparities Research Workforce in Hawaii
A program to mentor and support early-career researchers from Native Hawaiian, Pacific Islander, and Filipino communities to study health disparities in Hawaii.
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