Genetically Validated PCOS Subtypes for Better Diagnosis and Risk Stratification
Official title: Genetically Validated PCOS Subtypes: Data-Driven Clinical Translation for Improved Diagnosis and Comprehensive Risk Stratification
Funded at Icahn School of Medicine at Mount Sinai · NIH-11623556 · Data updated 2026-11-12
Aimed at women with polycystic ovary syndrome (PCOS), this project uses genetic data and patient characteristics to define distinct PCOS subtypes and improve how we diagnose and estimate risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2020 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $58,128 |
| NIH project number | 3R01HD100812-06S1 |
| Project ID | NIH-11623556 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women with PCOS who consent to genetic and health data analysis.
✕Less likely to help
Patients without PCOS or those unwilling to participate in genetic analyses may not benefit.
What this research studies
This project looks at PCOS, a common hormone condition that affects health across a woman’s life. Researchers group patients based on genetics and metabolic traits to identify distinct subtypes with different causes and risks. They plan to use data-driven methods and genetic risk scores to guide diagnosis and management. The work involves diverse populations to ensure findings apply broadly and may influence future clinical care. The goal is to translate these subtypes into clearer, personalized care strategies for PCOS.
Why it matters
Potential benefit: If successful, patients could receive more accurate diagnoses and personalized treatments tailored to their PCOS subtype.
How similar studies have gone: Previous work showed subtype-specific genetic patterns and preliminary risk scores, with independent validation supporting the approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Dunaif, Andrea — Icahn School of Medicine at Mount Sinai
- Study coordinator: Dunaif, Andrea
Related research
Other NIH-funded projects on the same topics.
-
Understanding how PCOS develops during adolescence
This grant looks at how polycystic ovary syndrome begins in teenagers and what early signs help doctors diagnose it accurately.
-
Genetically guided PCOS subtypes to improve diagnosis and risk stratification
Aims to use genetic patterns to identify PCOS subtypes so doctors can diagnose it more precisely and tailor risk predictions for each patient.
-
Using inositol to improve reproductive and metabolic health in women with PCOS
This study is looking at how taking inositol might help women with polycystic ovary syndrome (PCOS) by checking its effects on hormone levels and overall health over three months.
-
Understanding how dopamine affects reproductive hormone release in women with PCOS
This study is looking at how certain brain cells that control hormone release can help women with reproductive issues like PCOS and hypothalamic amenorrhea, and it’s testing if a compound that affects these cells can help balance hormone levels.
-
Investigating how genetic variations in gonadotropin pathways affect PCOS
This study is looking at how our genes might play a role in Polycystic Ovary Syndrome (PCOS) to help find better treatments for women dealing with this condition.
-
Examining how physical activity affects the risk of PCOS in young girls
This study is looking at how physical activity can help girls aged 8 to 10 who are at risk for Polycystic Ovary Syndrome (PCOS) by tracking their insulin and hormone levels while they try out a special exercise program to see if it can improve their health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.