Investigating how genetic variations in gonadotropin pathways affect PCOS
Official title: The effect of gonadotropin pathway genetic variation on PCOS pathogenesis
Funded at Northwestern University at Chicago · NIH-11069504 · Data updated 2026-11-12
This study is looking at how our genes might play a role in Polycystic Ovary Syndrome (PCOS) to help find better treatments for women dealing with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $44,187 |
| NIH project number | 1F31HD117594-01 |
| Project ID | NIH-11069504 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of reproductive age who have been diagnosed with PCOS.
✕Less likely to help
Patients who do not have PCOS or those with other unrelated reproductive disorders may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to Polycystic Ovary Syndrome (PCOS), a common hormonal disorder affecting many women of reproductive age. By utilizing advanced genetic sequencing techniques, the study aims to identify specific genetic variations that influence the gonadotropin signaling pathways, which are crucial for ovarian health and function. The goal is to uncover the underlying causes of PCOS, which may lead to more effective treatments tailored to individual genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and personalized treatment options for women suffering from PCOS.
How similar studies have gone: Previous research has shown promising results in identifying genetic factors associated with PCOS, indicating that this approach has potential for success.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Stokes, Giangela Maria — Northwestern University at Chicago
- Study coordinator: Stokes, Giangela Maria
Related research
Other NIH-funded projects on the same topics.
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Genetically Validated PCOS Subtypes for Better Diagnosis and Risk Stratification
Aimed at women with polycystic ovary syndrome (PCOS), this project uses genetic data and patient characteristics to define distinct PCOS subtypes and improve how we diagnose and estimate risk.
-
Understanding how PCOS develops during adolescence
This grant looks at how polycystic ovary syndrome begins in teenagers and what early signs help doctors diagnose it accurately.
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Genetically guided PCOS subtypes to improve diagnosis and risk stratification
Aims to use genetic patterns to identify PCOS subtypes so doctors can diagnose it more precisely and tailor risk predictions for each patient.
-
Using inositol to improve reproductive and metabolic health in women with PCOS
This study is looking at how taking inositol might help women with polycystic ovary syndrome (PCOS) by checking its effects on hormone levels and overall health over three months.
-
Understanding how dopamine affects reproductive hormone release in women with PCOS
This study is looking at how certain brain cells that control hormone release can help women with reproductive issues like PCOS and hypothalamic amenorrhea, and it’s testing if a compound that affects these cells can help balance hormone levels.
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Examining how physical activity affects the risk of PCOS in young girls
This study is looking at how physical activity can help girls aged 8 to 10 who are at risk for Polycystic Ovary Syndrome (PCOS) by tracking their insulin and hormone levels while they try out a special exercise program to see if it can improve their health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.