Investigating heart disease risk in people with HIV and tuberculosis
Coronary Atherosclerosis and Immune Activation in HIV and Tuberculosis Infection
This study is looking at how having both HIV and tuberculosis might increase the risk of heart problems, especially in people living in Lima, Peru, and aims to find out how these infections affect heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10902034 on NIH RePORTER |
What this research studies
This research focuses on understanding how co-infection with tuberculosis affects the risk of cardiovascular disease in individuals living with HIV. It aims to explore the relationship between latent tuberculosis infection and the development of atherosclerosis, a condition characterized by the buildup of plaques in the arteries. The study will involve patients in Lima, Peru, where both HIV and tuberculosis are prevalent, and will assess the impact of immune activation on heart health. By analyzing patient data and conducting experiments, the research seeks to uncover the mechanisms linking these infections to increased heart disease risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those who may also have latent tuberculosis infection.
Not a fit: Patients who do not have HIV or tuberculosis are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cardiovascular disease in people living with HIV who are also infected with tuberculosis.
How similar studies have performed: Previous research has indicated that latent tuberculosis infection is associated with increased cardiovascular risk in HIV-uninfected individuals, suggesting a potential for similar findings in this population.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Huaman Joo, Moises Arturo — University of Cincinnati
- Study coordinator: Huaman Joo, Moises Arturo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.