Investigating heart disease risk in people with HIV and tuberculosis
Official title: Coronary Atherosclerosis and Immune Activation in HIV and Tuberculosis Infection
Funded at University of Cincinnati · NIH-10902034 · Data updated 2026-11-12
This study is looking at how having both HIV and tuberculosis might increase the risk of heart problems, especially in people living in Lima, Peru, and aims to find out how these infections affect heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 2, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $607,624 |
| NIH project number | 5R01HL156779-03 |
| Project ID | NIH-10902034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV, particularly those who may also have latent tuberculosis infection.
✕Less likely to help
Patients who do not have HIV or tuberculosis are unlikely to benefit from this research.
What this research studies
This research focuses on understanding how co-infection with tuberculosis affects the risk of cardiovascular disease in individuals living with HIV. It aims to explore the relationship between latent tuberculosis infection and the development of atherosclerosis, a condition characterized by the buildup of plaques in the arteries. The study will involve patients in Lima, Peru, where both HIV and tuberculosis are prevalent, and will assess the impact of immune activation on heart health. By analyzing patient data and conducting experiments, the research seeks to uncover the mechanisms linking these infections to increased heart disease risk.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cardiovascular disease in people living with HIV who are also infected with tuberculosis.
How similar studies have gone: Previous research has indicated that latent tuberculosis infection is associated with increased cardiovascular risk in HIV-uninfected individuals, suggesting a potential for similar findings in this population.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Huaman Joo, Moises Arturo — University of Cincinnati
- Study coordinator: Huaman Joo, Moises Arturo
Related research
Other NIH-funded projects on the same topics.
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Coronary disease and immune activation in people with HIV and tuberculosis coinfection
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
-
Heart artery disease in people with HIV and latent tuberculosis
This project looks at whether people living with HIV who also have latent tuberculosis develop more artery plaque and heart disease than those without tuberculosis.
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Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
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Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
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Air pollution and tuberculosis spread in Kampala, Uganda
This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.
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Air pollution and TB spread in Ugandan urban slums
This project explores whether exposure to air pollution makes tuberculosis more likely to spread within households in a crowded Ugandan slum.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.