Heart artery disease in people with HIV and latent tuberculosis
Official title: Coronary Atherosclerosis and Immune Activation in HIV and Tuberculosis Infection
Funded at University of Cincinnati · NIH-11170699 · Data updated 2026-11-12
This project looks at whether people living with HIV who also have latent tuberculosis develop more artery plaque and heart disease than those without tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 2, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $589,109 |
| NIH project number | 5R01HL156779-04 |
| Project ID | NIH-11170699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV in Lima, Peru, whether they have latent tuberculosis or not, are the intended participants for this project.
✕Less likely to help
People without HIV, those outside the study region, or those with active tuberculosis (rather than latent infection) are unlikely to be eligible or to receive direct benefit from this project.
What this research studies
You would be asked to join a group of adults living with HIV in Lima, Peru, some who have latent tuberculosis (LTBI) and some who do not. Researchers will use heart artery imaging and blood tests that measure immune activation and inflammation to compare plaque burden and plaque features between the groups. They will also analyze immune cell changes linked to plaque development using blood samples and lab studies informed by earlier mouse experiments. The goal is to link latent TB-related immune changes to artery plaque and risk of obstructive coronary disease in people with HIV.
Why it matters
Potential benefit: If successful, this work could identify latent tuberculosis as a contributor to heart artery disease in people with HIV and point to new ways to reduce that risk.
How similar studies have gone: Previous data linked latent tuberculosis to higher heart attack risk and more obstructive coronary disease in people without HIV and mouse experiments showed more plaque with persistent mycobacterial infection, but this approach has not yet been proven in people living with HIV.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Huaman Joo, Moises Arturo — University of Cincinnati
- Study coordinator: Huaman Joo, Moises Arturo
Related research
Other NIH-funded projects on the same topics.
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Coronary disease and immune activation in people with HIV and tuberculosis coinfection
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
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Investigating heart disease risk in people with HIV and tuberculosis
This study is looking at how having both HIV and tuberculosis might increase the risk of heart problems, especially in people living in Lima, Peru, and aims to find out how these infections affect heart health.
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Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
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Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
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Air pollution and tuberculosis spread in Kampala, Uganda
This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.
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Air pollution and TB spread in Ugandan urban slums
This project explores whether exposure to air pollution makes tuberculosis more likely to spread within households in a crowded Ugandan slum.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.