Heart artery disease in people with HIV and latent tuberculosis
Coronary Atherosclerosis and Immune Activation in HIV and Tuberculosis Infection
This project looks at whether people living with HIV who also have latent tuberculosis develop more artery plaque and heart disease than those without tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11170699 on NIH RePORTER |
What this research studies
You would be asked to join a group of adults living with HIV in Lima, Peru, some who have latent tuberculosis (LTBI) and some who do not. Researchers will use heart artery imaging and blood tests that measure immune activation and inflammation to compare plaque burden and plaque features between the groups. They will also analyze immune cell changes linked to plaque development using blood samples and lab studies informed by earlier mouse experiments. The goal is to link latent TB-related immune changes to artery plaque and risk of obstructive coronary disease in people with HIV.
Who could benefit from this research
Good fit: Adults living with HIV in Lima, Peru, whether they have latent tuberculosis or not, are the intended participants for this project.
Not a fit: People without HIV, those outside the study region, or those with active tuberculosis (rather than latent infection) are unlikely to be eligible or to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could identify latent tuberculosis as a contributor to heart artery disease in people with HIV and point to new ways to reduce that risk.
How similar studies have performed: Previous data linked latent tuberculosis to higher heart attack risk and more obstructive coronary disease in people without HIV and mouse experiments showed more plaque with persistent mycobacterial infection, but this approach has not yet been proven in people living with HIV.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Huaman Joo, Moises Arturo — University of Cincinnati
- Study coordinator: Huaman Joo, Moises Arturo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.