Investigating how certain proteins in blood contribute to blood clots and aortic aneurysms
Official title: Role of RIP3-laden extracellular vesicles in thrombosis and aortic aneurysm
Funded at University of Wisconsin-Madison · NIH-10630195 · Data updated 2026-11-12
This study is looking at a protein called RIP3 in blood samples from people with aortic aneurysms to see how it affects blood clotting and could help us find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 15, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $472,770 |
| NIH project number | 5R01HL149404-04 |
| Project ID | NIH-10630195 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with aortic aneurysms who may be experiencing complications related to blood clotting.
✕Less likely to help
Patients without aortic aneurysms or those not experiencing thrombotic complications may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific protein, RIP3, found in extracellular vesicles from blood in the formation of blood clots associated with aortic aneurysms. Researchers will explore how these vesicles influence coagulation processes and contribute to the weakening of the aorta. By conducting laboratory experiments, they aim to uncover the mechanisms behind thrombus formation in patients with aortic aneurysms, which could lead to new therapeutic strategies. The study involves analyzing blood samples from patients to correlate RIP3 levels with clotting activity.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the severity of aortic aneurysms and improve patient outcomes related to blood clotting.
How similar studies have gone: Previous research has shown promising results in understanding thrombus formation in similar contexts, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Liu, Bo — University of Wisconsin-Madison
- Study coordinator: Liu, Bo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.