CARD9 and Ankylosing Spondylitis: understanding immune signals in veterans
Official title: CARD9 in Ankylosing Spondylitis
Funded at VA Eastern Colorado Health Care System · NIH-11400852 · Data updated 2026-11-12
A study with veterans who have ankylosing spondylitis will explore how immune signals linked to CARD9 may influence disease and treatment responses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2027 |
| NIH project number | 5I01BX006436-03 |
| Project ID | NIH-11400852 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with ankylosing spondylitis, especially veterans, who are considering or currently on anti-inflammatory biologic therapies.
✕Less likely to help
Patients whose disease does not involve the studied immune pathways may see limited benefit.
What this research studies
This project looks at how specific immune pathways may drive back pain and joint changes in ankylosing spondylitis. Researchers will examine the innate immune signals that lead to inflammatory Th17 cells and how they respond to existing therapies. The study aims to identify genetic and molecular markers that predict which treatments will work best for individual patients. The work could point to new biomarkers that help tailor therapy and improve quality of life for people with AS.
Why it matters
Potential benefit: If successful, patients may get faster, more effective treatment decisions and better symptom control.
How similar studies have gone: Prior work shows that understanding immune pathways can guide personalized therapy, but reliable predictors are still needed.
Where this research is happening
-
VA Eastern Colorado Health Care System
Aurora, United States Active
Researchers
- Principal investigator: Napier, Ruth — VA Eastern Colorado Health Care System
- Study coordinator: Napier, Ruth
Related research
Other NIH-funded projects on the same topics.
-
How the gene CARD9 may affect ankylosing spondylitis
Researchers are looking at whether differences in a gene called CARD9 help explain inflammation and treatment response in people with ankylosing spondylitis.
-
Understanding how spinal disease progresses in ankylosing spondylitis
This study is looking at how ankylosing spondylitis affects the spine over time, and it aims to find specific markers in your blood that can help predict how severe the damage might get, so we can catch problems early and take better care of you.
-
Investigating the role of CARD9 in Ankylosing Spondylitis
This study is looking at how genes and immune cells affect Ankylosing Spondylitis in veterans, with the goal of finding better ways to predict and personalize treatments for this painful condition.
-
HB0017 Injection safety and PK in low-weight adults at different injection sites
This early-phase study tests a single subcutaneous HB0017 injection in healthy, low-weight adults and compares how the body processes the drug when injected at different sites.
-
Surface topography and spine damage in radiographic axial spondyloarthritis
This study tests whether a radiation-free 3D surface topography method can reflect spine damage and sagittal balance in adults with radiographic axial spondyloarthritis.
-
New modified acupotomy method for ankylosing spondylitis
This study tests whether a modified ultrasound-guided acupotomy can reduce disease activity and symptoms in adults (18–75) with active ankylosing spondylitis (BASDAI ≥4) compared with a sham procedure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.