How the gene CARD9 may affect ankylosing spondylitis
CARD9 in Ankylosing Spondylitis
Researchers are looking at whether differences in a gene called CARD9 help explain inflammation and treatment response in people with ankylosing spondylitis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11116936 on NIH RePORTER |
What this research studies
This project will examine blood and other samples from people with ankylosing spondylitis to study immune signals linked to the gene CARD9. The team will compare molecular and genetic markers tied to Th17 immune responses that drive spinal inflammation and pain. They aim to find markers that predict who responds best to approved biologic treatments like IL-17 blockers. Results may guide more personalized treatment choices for patients, especially Veterans served at the Portland VA.
Who could benefit from this research
Good fit: Adults with a diagnosis of ankylosing spondylitis (axial spondyloarthritis), particularly Veterans who can provide clinical information and biological samples, would be ideal candidates.
Not a fit: People without ankylosing spondylitis or those unwilling/unable to provide samples or clinical data are unlikely to benefit directly from participating.
Why it matters
Potential benefit: If successful, this work could lead to biomarkers that help match patients with the biologic drug most likely to reduce their inflammation and pain.
How similar studies have performed: Blocking IL-17 already helps many patients with ankylosing spondylitis, but using CARD9-related biomarkers to guide treatment is a newer approach that has not yet been proven in patients.
Where this research is happening
Portland, United States
- Portland VA Medical Center — Portland, United States (Active)
Researchers
- Principal investigator: Napier, Ruth — Portland VA Medical Center
- Study coordinator: Napier, Ruth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.