Investigating the role of CARD9 in Ankylosing Spondylitis
Official title: CARD9 in Ankylosing Spondylitis
Funded at Portland VA Medical Center · NIH-10807453 · Data updated 2026-11-12
This study is looking at how genes and immune cells affect Ankylosing Spondylitis in veterans, with the goal of finding better ways to predict and personalize treatments for this painful condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01BX006436-01 |
| Project ID | NIH-10807453 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with Ankylosing Spondylitis who are experiencing chronic pain and inflammation.
✕Less likely to help
Patients who do not have Ankylosing Spondylitis or related inflammatory arthritis conditions may not benefit from this research.
What this research studies
This research focuses on Ankylosing Spondylitis (AS), a painful inflammatory arthritis that affects many veterans. It aims to understand the genetic and molecular factors that contribute to the disease, particularly the role of certain immune cells that produce inflammatory signals. By identifying biomarkers that predict how well patients respond to existing treatments, the research seeks to improve personalized treatment strategies. The study will involve analyzing immune responses and genetic factors in patients with AS to uncover new insights into the disease's mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients suffering from Ankylosing Spondylitis.
How similar studies have gone: Previous research has shown promise in understanding immune mechanisms in similar autoimmune diseases, suggesting potential for success in this area as well.
Where this research is happening
-
Portland VA Medical Center
Portland, United States Active
Researchers
- Principal investigator: Napier, Ruth — Portland VA Medical Center
- Study coordinator: Napier, Ruth
Related research
Other NIH-funded projects on the same topics.
-
CARD9 and Ankylosing Spondylitis: understanding immune signals in veterans
A study with veterans who have ankylosing spondylitis will explore how immune signals linked to CARD9 may influence disease and treatment responses.
-
How the gene CARD9 may affect ankylosing spondylitis
Researchers are looking at whether differences in a gene called CARD9 help explain inflammation and treatment response in people with ankylosing spondylitis.
-
Understanding how spinal disease progresses in ankylosing spondylitis
This study is looking at how ankylosing spondylitis affects the spine over time, and it aims to find specific markers in your blood that can help predict how severe the damage might get, so we can catch problems early and take better care of you.
-
HB0017 Injection safety and PK in low-weight adults at different injection sites
This early-phase study tests a single subcutaneous HB0017 injection in healthy, low-weight adults and compares how the body processes the drug when injected at different sites.
-
Surface topography and spine damage in radiographic axial spondyloarthritis
This study tests whether a radiation-free 3D surface topography method can reflect spine damage and sagittal balance in adults with radiographic axial spondyloarthritis.
-
New modified acupotomy method for ankylosing spondylitis
This study tests whether a modified ultrasound-guided acupotomy can reduce disease activity and symptoms in adults (18–75) with active ankylosing spondylitis (BASDAI ≥4) compared with a sham procedure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.