Understanding how spinal disease progresses in ankylosing spondylitis
Molecular Profiling of Spinal Disease Progression in Ankylosing Spondylitis
This study is looking at how ankylosing spondylitis affects the spine over time, and it aims to find specific markers in your blood that can help predict how severe the damage might get, so we can catch problems early and take better care of you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11039825 on NIH RePORTER |
What this research studies
This research investigates the progression of spinal disease in patients with ankylosing spondylitis (AS), a chronic inflammatory condition affecting the spine. By analyzing blood samples, the study aims to identify molecular profiles and biomarkers that can predict the severity of spinal damage over time. The approach includes advanced techniques like RNA sequencing and proteomics to uncover the biological factors influencing disease progression. Ultimately, the goal is to develop tools that help predict spinal disease outcomes before significant damage occurs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ankylosing spondylitis who are experiencing varying degrees of spinal disease progression.
Not a fit: Patients with ankylosing spondylitis who have already experienced irreversible spinal damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier interventions and personalized treatment strategies for patients with ankylosing spondylitis.
How similar studies have performed: Previous research has shown promise in using molecular profiling to predict disease outcomes in other chronic inflammatory conditions, suggesting potential success for this approach in ankylosing spondylitis.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Hwang, Mark Chiawei — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Hwang, Mark Chiawei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.