Identifying unique subtypes of kidney injury in children with sepsis
Developing a Precision Medicine Approach to Pediatric Sepsis-Associated Acute Kidney Injury: Identification of Unique Subphenotypes and Strategies for Bedside Implementation
This study is looking at children with septic shock and kidney problems to find better ways to treat them by understanding the different types of their condition, so we can choose the right medicines to help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10875426 on NIH RePORTER |
What this research studies
This research focuses on children who experience septic shock and sepsis-associated acute kidney injury (SA-AKI), a serious condition with limited treatment options. The project aims to develop a precision medicine approach by analyzing clinical and biomarker data to identify distinct subphenotypes of SA-AKI. By understanding these subtypes, the research seeks to improve the selection of medications used at the bedside, ultimately enhancing treatment strategies for affected children. The findings will also pave the way for future studies aimed at improving outcomes for pediatric patients suffering from septic shock.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who are admitted to the pediatric intensive care unit with septic shock and acute kidney injury.
Not a fit: Patients who do not have septic shock or acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children suffering from sepsis-associated acute kidney injury.
How similar studies have performed: Previous research in adult populations has shown promise in using precision medicine approaches for sepsis, suggesting potential success for similar strategies in pediatric patients.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Stanski, Natalja L. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Stanski, Natalja L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.