Identifying unique subtypes of kidney injury in children with sepsis
Official title: Developing a Precision Medicine Approach to Pediatric Sepsis-Associated Acute Kidney Injury: Identification of Unique Subphenotypes and Strategies for Bedside Implementation
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10875426 · Data updated 2026-11-12
This study is looking at children with septic shock and kidney problems to find better ways to treat them by understanding the different types of their condition, so we can choose the right medicines to help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $191,876 |
| NIH project number | 5K23GM151444-02 |
| Project ID | NIH-10875426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-21 who are admitted to the pediatric intensive care unit with septic shock and acute kidney injury.
✕Less likely to help
Patients who do not have septic shock or acute kidney injury may not benefit from this research.
What this research studies
This research focuses on children who experience septic shock and sepsis-associated acute kidney injury (SA-AKI), a serious condition with limited treatment options. The project aims to develop a precision medicine approach by analyzing clinical and biomarker data to identify distinct subphenotypes of SA-AKI. By understanding these subtypes, the research seeks to improve the selection of medications used at the bedside, ultimately enhancing treatment strategies for affected children. The findings will also pave the way for future studies aimed at improving outcomes for pediatric patients suffering from septic shock.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children suffering from sepsis-associated acute kidney injury.
How similar studies have gone: Previous research in adult populations has shown promise in using precision medicine approaches for sepsis, suggesting potential success for similar strategies in pediatric patients.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Stanski, Natalja L. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Stanski, Natalja L.
Related research
Other NIH-funded projects on the same topics.
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Biomarkers to identify kidney injury sub-types in sepsis patients
This grant tests whether two distinct kidney injury sub-types in sepsis can be found early in emergency care and used to guide better treatment.
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Understanding Different Types of Kidney Injury in Sepsis to Improve Care
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-
Understanding the Gut Microbiome in Sepsis-Related Kidney Injury
This research explores how the bacteria in your gut might influence why some people with severe infections develop kidney damage.
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Diagnosing and staging kidney injury related to sepsis
This study is looking to find new ways to quickly and accurately diagnose kidney damage in people with sepsis by testing blood samples from mice, which could lead to a simple blood test for doctors to use in treating patients.
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Investigating the gut microbiome's role in kidney injury during sepsis
This study is looking at how the bacteria in your gut might affect kidney problems in people with sepsis, and it aims to find out which specific bacteria could help predict how serious those kidney issues might be.
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Identifying different types of kidney injury caused by sepsis to improve treatment outcomes.
This study is looking at how different types of kidney problems caused by sepsis can be treated better by using specific tests to find out what each patient needs, so that doctors can give the best care right away in emergency rooms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.