Investigating the gut microbiome's role in kidney injury during sepsis
Official title: A translational approach to interrogate the gut microbiome in sepsis-associated acute kidney injury
Funded at University of Michigan at Ann Arbor · NIH-10995018 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might affect kidney problems in people with sepsis, and it aims to find out which specific bacteria could help predict how serious those kidney issues might be.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,094 |
| NIH project number | 1F31DK138603-01A1 |
| Project ID | NIH-10995018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with sepsis who are at risk of developing acute kidney injury.
✕Less likely to help
Patients with sepsis who do not develop acute kidney injury may not benefit from this research.
What this research studies
This research explores how the gut microbiome may influence the development of acute kidney injury (AKI) in patients suffering from sepsis. By analyzing bacterial communities in both animal models and human cohorts, the study aims to identify specific gut bacteria that could predict the severity of kidney injury. The approach includes advanced gene sequencing techniques to profile the microbiome and assess its relationship with kidney health. This could lead to better understanding and management of sepsis-related complications.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating kidney injury in septic patients.
How similar studies have gone: Previous research has shown promising results in understanding the gut microbiome's impact on various health conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Winner, Katherine — University of Michigan at Ann Arbor
- Study coordinator: Winner, Katherine
Related research
Other NIH-funded projects on the same topics.
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Understanding the Gut Microbiome in Sepsis-Related Kidney Injury
This research explores how the bacteria in your gut might influence why some people with severe infections develop kidney damage.
-
Biomarkers to identify kidney injury sub-types in sepsis patients
This grant tests whether two distinct kidney injury sub-types in sepsis can be found early in emergency care and used to guide better treatment.
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How gut bacteria affect muscle loss during sepsis
This study is looking at how the bacteria in your gut might affect muscle loss in people who are dealing with sepsis, with the hope of finding ways to help keep muscles strong and improve recovery.
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Understanding Different Types of Kidney Injury in Sepsis to Improve Care
This work aims to find specific types of acute kidney injury in patients with sepsis to help doctors provide more personalized and effective treatments.
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Diagnosing and staging kidney injury related to sepsis
This study is looking to find new ways to quickly and accurately diagnose kidney damage in people with sepsis by testing blood samples from mice, which could lead to a simple blood test for doctors to use in treating patients.
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Understanding how gut bacteria affect muscle loss after sepsis
This study is looking at how the bacteria in your gut might affect muscle loss after a serious infection called sepsis, and it's for people who are recovering from this condition to help find ways to keep their muscles healthy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.