Investigating the gut microbiome's role in kidney injury during sepsis
A translational approach to interrogate the gut microbiome in sepsis-associated acute kidney injury
This study is looking at how the bacteria in your gut might affect kidney problems in people with sepsis, and it aims to find out which specific bacteria could help predict how serious those kidney issues might be.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10995018 on NIH RePORTER |
What this research studies
This research explores how the gut microbiome may influence the development of acute kidney injury (AKI) in patients suffering from sepsis. By analyzing bacterial communities in both animal models and human cohorts, the study aims to identify specific gut bacteria that could predict the severity of kidney injury. The approach includes advanced gene sequencing techniques to profile the microbiome and assess its relationship with kidney health. This could lead to better understanding and management of sepsis-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis who are at risk of developing acute kidney injury.
Not a fit: Patients with sepsis who do not develop acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating kidney injury in septic patients.
How similar studies have performed: Previous research has shown promising results in understanding the gut microbiome's impact on various health conditions, suggesting potential for success in this novel approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Winner, Katherine — University of Michigan at Ann Arbor
- Study coordinator: Winner, Katherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.