Understanding Different Types of Kidney Injury in Sepsis to Improve Care
Identification and Validation of Biological Sub-phenotypes of Sepsis-induced Acute Kidney Injury: A Precision Medicine Approach to Improve Clinical Outcomes
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11141132
This work aims to find specific types of acute kidney injury in patients with sepsis to help doctors provide more personalized and effective treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11141132 on ClinicalTrials.gov |
What this research studies
Acute kidney injury (AKI) is a serious problem for patients with sepsis, often leading to longer hospital stays and even death, and currently, there are no specific medications to treat it. We believe that AKI isn't just one condition but actually includes different types, or 'sub-phenotypes,' that respond differently to treatments. Our team has already found two such sub-phenotypes using blood markers, and these findings have been confirmed by other researchers. This project will expand our search for more markers to identify these specific AKI types even earlier, right in the emergency room, which is a crucial time for intervention.
Who could benefit from this research
Good fit: This research is relevant for patients who experience acute kidney injury as a complication of sepsis.
Not a fit: Patients whose kidney injury is not related to sepsis or who do not have acute kidney injury may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways for doctors to quickly identify specific types of kidney injury in sepsis patients, allowing for more targeted and effective treatments.
How similar studies have performed: Preliminary findings from this group and an independent research group have already shown that these specific kidney injury sub-phenotypes are reproducible and can predict patient outcomes and treatment responses.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BHATRAJU, PAVAN KUMAR — UNIVERSITY OF WASHINGTON
- Study coordinator: BHATRAJU, PAVAN KUMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.