Diagnosing and staging kidney injury related to sepsis
Transcriptomic Diagnosis and Staging of Sepsis-Associated Acute Kidney Injury
This study is looking to find new ways to quickly and accurately diagnose kidney damage in people with sepsis by testing blood samples from mice, which could lead to a simple blood test for doctors to use in treating patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11067749 on NIH RePORTER |
What this research studies
This research aims to improve the diagnosis and staging of acute kidney injury (AKI) that occurs in patients with sepsis. By analyzing blood samples from mice, researchers will identify specific biomarkers that indicate kidney damage. These findings will then be translated to human patients to create a liquid biopsy test that can accurately diagnose and stage sepsis-associated AKI. This innovative approach seeks to provide better tools for clinicians to manage and treat patients suffering from this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis who are at risk of developing acute kidney injury.
Not a fit: Patients with kidney injury not related to sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnosis of kidney injury in sepsis patients, potentially improving treatment outcomes.
How similar studies have performed: Previous research has shown promise in using blood-based biomarkers for diagnosing various conditions, indicating potential success for this novel approach.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Janosevic, Danielle — Indiana University Indianapolis
- Study coordinator: Janosevic, Danielle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.