Diagnosing and staging kidney injury related to sepsis
Official title: Transcriptomic Diagnosis and Staging of Sepsis-Associated Acute Kidney Injury
Funded at Indiana University Indianapolis · NIH-11067749 · Data updated 2026-11-12
This study is looking to find new ways to quickly and accurately diagnose kidney damage in people with sepsis by testing blood samples from mice, which could lead to a simple blood test for doctors to use in treating patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | April 15, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $156,453 |
| NIH project number | 5K08DK139369-02 |
| Project ID | NIH-11067749 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with sepsis who are at risk of developing acute kidney injury.
✕Less likely to help
Patients with kidney injury not related to sepsis may not benefit from this research.
What this research studies
This research aims to improve the diagnosis and staging of acute kidney injury (AKI) that occurs in patients with sepsis. By analyzing blood samples from mice, researchers will identify specific biomarkers that indicate kidney damage. These findings will then be translated to human patients to create a liquid biopsy test that can accurately diagnose and stage sepsis-associated AKI. This innovative approach seeks to provide better tools for clinicians to manage and treat patients suffering from this serious condition.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnosis of kidney injury in sepsis patients, potentially improving treatment outcomes.
How similar studies have gone: Previous research has shown promise in using blood-based biomarkers for diagnosing various conditions, indicating potential success for this novel approach.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Janosevic, Danielle — Indiana University Indianapolis
- Study coordinator: Janosevic, Danielle
Related research
Other NIH-funded projects on the same topics.
-
Biomarkers to identify kidney injury sub-types in sepsis patients
This grant tests whether two distinct kidney injury sub-types in sepsis can be found early in emergency care and used to guide better treatment.
-
Understanding Different Types of Kidney Injury in Sepsis to Improve Care
This work aims to find specific types of acute kidney injury in patients with sepsis to help doctors provide more personalized and effective treatments.
-
Understanding the Gut Microbiome in Sepsis-Related Kidney Injury
This research explores how the bacteria in your gut might influence why some people with severe infections develop kidney damage.
-
Investigating the gut microbiome's role in kidney injury during sepsis
This study is looking at how the bacteria in your gut might affect kidney problems in people with sepsis, and it aims to find out which specific bacteria could help predict how serious those kidney issues might be.
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Identifying different types of kidney injury caused by sepsis to improve treatment outcomes.
This study is looking at how different types of kidney problems caused by sepsis can be treated better by using specific tests to find out what each patient needs, so that doctors can give the best care right away in emergency rooms.
-
Identifying unique subtypes of kidney injury in children with sepsis
This study is looking at children with septic shock and kidney problems to find better ways to treat them by understanding the different types of their condition, so we can choose the right medicines to help them feel better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.