Identifying different types of kidney injury caused by sepsis to improve treatment outcomes.
Identification and Validation of Biological Sub-phenotypes of Sepsis-induced Acute Kidney Injury: A Precision Medicine Approach to Improve Clinical Outcomes
This study is looking at how different types of kidney problems caused by sepsis can be treated better by using specific tests to find out what each patient needs, so that doctors can give the best care right away in emergency rooms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10885994 on NIH RePORTER |
What this research studies
This research focuses on understanding the different biological sub-types of acute kidney injury (AKI) that occur due to sepsis. By identifying these sub-phenotypes, the study aims to improve patient outcomes through precision medicine, which tailors treatment based on individual characteristics. The researchers will analyze plasma markers and other biological indicators to differentiate between these sub-phenotypes, potentially leading to more effective therapies. The goal is to implement these findings in emergency rooms to enhance early intervention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing sepsis and acute kidney injury, particularly those admitted to emergency departments.
Not a fit: Patients with acute kidney injury not related to sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from sepsis-induced acute kidney injury, ultimately improving survival rates and reducing the need for dialysis.
How similar studies have performed: Previous research has shown success in identifying sub-phenotypes of acute kidney injury, indicating that this approach has potential for meaningful advancements in treatment.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Bhatraju, Pavan Kumar — University of Washington
- Study coordinator: Bhatraju, Pavan Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.