Identifying different types of kidney injury caused by sepsis to improve treatment outcomes.
Official title: Identification and Validation of Biological Sub-phenotypes of Sepsis-induced Acute Kidney Injury: A Precision Medicine Approach to Improve Clinical Outcomes
Funded at University of Washington · NIH-10885994 · Data updated 2026-11-12
This study is looking at how different types of kidney problems caused by sepsis can be treated better by using specific tests to find out what each patient needs, so that doctors can give the best care right away in emergency rooms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $488,097 |
| NIH project number | 5R01DK133177-03 |
| Project ID | NIH-10885994 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing sepsis and acute kidney injury, particularly those admitted to emergency departments.
✕Less likely to help
Patients with acute kidney injury not related to sepsis may not benefit from this research.
What this research studies
This research focuses on understanding the different biological sub-types of acute kidney injury (AKI) that occur due to sepsis. By identifying these sub-phenotypes, the study aims to improve patient outcomes through precision medicine, which tailors treatment based on individual characteristics. The researchers will analyze plasma markers and other biological indicators to differentiate between these sub-phenotypes, potentially leading to more effective therapies. The goal is to implement these findings in emergency rooms to enhance early intervention and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from sepsis-induced acute kidney injury, ultimately improving survival rates and reducing the need for dialysis.
How similar studies have gone: Previous research has shown success in identifying sub-phenotypes of acute kidney injury, indicating that this approach has potential for meaningful advancements in treatment.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Bhatraju, Pavan Kumar — University of Washington
- Study coordinator: Bhatraju, Pavan Kumar
Related research
Other NIH-funded projects on the same topics.
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Biomarkers to identify kidney injury sub-types in sepsis patients
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Understanding Different Types of Kidney Injury in Sepsis to Improve Care
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Understanding the Gut Microbiome in Sepsis-Related Kidney Injury
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Investigating the gut microbiome's role in kidney injury during sepsis
This study is looking at how the bacteria in your gut might affect kidney problems in people with sepsis, and it aims to find out which specific bacteria could help predict how serious those kidney issues might be.
-
Identifying unique subtypes of kidney injury in children with sepsis
This study is looking at children with septic shock and kidney problems to find better ways to treat them by understanding the different types of their condition, so we can choose the right medicines to help them feel better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.