Antiplatelet Therapy in Spontaneous Coronary Artery Dissection (APT-SCAD)
Official title: 1/2- Antiplatelet Therapy in Spontaneous Coronary Artery Dissection (APT-SCAD)
Funded at Icahn School of Medicine at Mount Sinai · NIH-11451750 · Data updated 2026-11-12
This project tests whether a stronger, one-year antiplatelet treatment plan is safer and more effective for people with SCAD-related heart trouble, compared with a shorter, aspirin-only approach.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 5, 2026 |
| Project end | July 31, 2033 |
| Funding year | 2026 |
| Award (this year) | $1,276,233 |
| NIH project number | 1U24HL181196-01A1 |
| Project ID | NIH-11451750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with SCAD who were treated conservatively after an acute event and are suitable for antiplatelet therapy.
✕Less likely to help
Patients who require immediate invasive treatment or have contraindications to antiplatelet medications may not benefit from this trial.
What this research studies
Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic heart condition that mostly affects younger women and can cause heart muscle damage. The study compares two antiplatelet strategies after an initial SCAD event: an intensive plan with dual antiplatelet therapy for 3 months followed by clopidogrel for 9 months, versus a moderate plan with aspirin alone for 3 months. By enrolling patients who have been treated without major intervention, researchers will monitor outcomes such as recurrent events and safety signals to determine which approach provides better short- and long-term protection. The goal is to establish evidence-based guidance for medical management of SCAD after an ACS presentation.
Why it matters
Potential benefit: If successful, the trial could clarify a safer and more effective antiplatelet strategy for SCAD patients, potentially reducing recurrent events and improving recovery.
How similar studies have gone: Observational data suggest varying outcomes with different antiplatelet regimens in SCAD, but rigorous randomized evidence is needed and this trial aims to provide it.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Gelijns, Anne Christine — Icahn School of Medicine at Mount Sinai
- Study coordinator: Gelijns, Anne Christine
Related research
Other NIH-funded projects on the same topics.
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Antiplatelet therapy after spontaneous SCAD
This study tests whether a longer, more intensive antiplatelet plan helps people who had SCAD and are treated without surgery.
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Investigating heart and blood vessel health in women with spontaneous coronary artery dissection
This study is looking at how the blood vessels and heart work in women who have had spontaneous coronary artery dissection (SCAD) to find out more about their unique traits, especially when they’re active or under stress, so we can improve treatment options for them.
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Survey of physical activity and quality of life for people with fibromuscular dysplasia
This national survey asks adults with fibromuscular dysplasia to see if activity restrictions affect their quality of life and emotional well-being.
-
Exercise responses in people with spontaneous coronary artery dissection or fibromuscular dysplasia
This study will test whether short sessions of different aerobic and resistance exercise change breathing, heart and blood pressure responses and symptoms in people with SCAD or FMD.
-
Stress contrast echocardiography in adults with prior SCAD
This project will use stress contrast echocardiography to see if small-vessel heart blood flow and blood-pressure responses during stress are different in adults who had spontaneous coronary artery dissection (SCAD) compared with healthy adults.
-
Remote exercise program after spontaneous coronary artery dissection
This study tests a remote exercise program to see if it’s doable for women recovering from SCAD events.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.