Antiplatelet therapy after spontaneous SCAD

Who could benefit from this research

What this research studies

Spontaneous coronary artery dissection (SCAD) can cause heart problems, especially in younger women. The trial compares an intensive 12-month antiplatelet plan (DAPT for 3 months, then clopidogrel for 9 months) with a shorter 3-month aspirin-only plan in patients whose SCAD was managed without intervention. Researchers will monitor outcomes like recurrent events and bleeding to see which approach is safer and more effective. The goal is to guide doctors on the best medicines to prevent future problems after SCAD. Participation would involve follow-up visits and medication adherence over a year.

Why it matters

Where this research is happening

• Icahn School of Medicine at Mount Sinai
  New York, United States Active

Researchers

• Principal investigator: Mehran, Roxana — Icahn School of Medicine at Mount Sinai
• Study coordinator: Mehran, Roxana

Related research

Other NIH-funded projects on the same topics.

• Antiplatelet Therapy in Spontaneous Coronary Artery Dissection (APT-SCAD)

  This project tests whether a stronger, one-year antiplatelet treatment plan is safer and more effective for people with SCAD-related heart trouble, compared with a shorter, aspirin-only approach.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11451750

• Investigating heart and blood vessel health in women with spontaneous coronary artery dissection

  This study is looking at how the blood vessels and heart work in women who have had spontaneous coronary artery dissection (SCAD) to find out more about their unique traits, especially when they’re active or under stress, so we can improve treatment options for them.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10908254

• Survey of physical activity and quality of life for people with fibromuscular dysplasia

  This national survey asks adults with fibromuscular dysplasia to see if activity restrictions affect their quality of life and emotional well-being.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07529691

• Exercise responses in people with spontaneous coronary artery dissection or fibromuscular dysplasia

  This study will test whether short sessions of different aerobic and resistance exercise change breathing, heart and blood pressure responses and symptoms in people with SCAD or FMD.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07526766

• Stress contrast echocardiography in adults with prior SCAD

  This project will use stress contrast echocardiography to see if small-vessel heart blood flow and blood-pressure responses during stress are different in adults who had spontaneous coronary artery dissection (SCAD) compared with healthy adults.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07178509

• Remote exercise program after spontaneous coronary artery dissection

  This study tests a remote exercise program to see if it’s doable for women recovering from SCAD events.

  Recruiting University of Leicester · Leicester, Leicestershire · NCT06955663

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.