Investigating heart and blood vessel health in women with spontaneous coronary artery dissection
Official title: The Vascular, Autonomic, and Myocardial Phenotypes in Women with Myocardial Infarction due to Spontaneous Coronary Artery Dissection
Funded at Mayo Clinic Rochester · NIH-10908254 · Data updated 2026-11-12
This study is looking at how the blood vessels and heart work in women who have had spontaneous coronary artery dissection (SCAD) to find out more about their unique traits, especially when they’re active or under stress, so we can improve treatment options for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $160,894 |
| NIH project number | 5K23HL155506-03 |
| Project ID | NIH-10908254 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have a history of spontaneous coronary artery dissection.
✕Less likely to help
Patients who do not have a history of spontaneous coronary artery dissection or related cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the unique characteristics of blood vessels and heart function in women who have experienced spontaneous coronary artery dissection (SCAD). The study aims to assess how these women’s arteries are structured and how they function, particularly under stress or during physical activity. By analyzing data from the largest SCAD registry, the research will help identify specific vascular and autonomic traits that could inform better treatment options. The principal investigator, Dr. Tweet, will also enhance her skills in data analysis and scientific leadership throughout the project.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for women suffering from SCAD.
How similar studies have gone: Previous research has shown promising results in understanding coronary artery disease in women, but this specific focus on SCAD is relatively novel.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Tweet, Marysia S — Mayo Clinic Rochester
- Study coordinator: Tweet, Marysia S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.