Anticoagulation in ICH survivors with AF and small vessel disease features
Official title: Anticoagulation in Intracerebral Hemorrhage Survivors with Atrial Fibrillation and Imaging Features of Cerebral Amyloid Angiopathy and Small Vessel Disease
Funded at Yale University · NIH-11333049 · Data updated 2026-11-12
A study to understand how anticoagulant therapy affects people who have had a non-traumatic brain bleed and also have atrial fibrillation, focusing on imaging signs of small vessel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 9, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $505,658 |
| NIH project number | 5R01NS140459-02 |
| Project ID | NIH-11333049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of non-traumatic intracerebral hemorrhage, atrial fibrillation, and specific brain imaging markers of small vessel disease.
✕Less likely to help
Patients without AF, without imaging signs of CSVD, or those not considered for anticoagulation may not benefit from this research.
What this research studies
This project looks at adults who survived a non-traumatic intracerebral hemorrhage and have atrial fibrillation. It will use MRI features such as microbleeds and white matter changes to see how these CSVD traits influence the benefits or risks of continuing anticoagulation. By analyzing data from two ongoing trials, the team will identify which CSVD patterns predict better or worse outcomes with anticoagulation and develop tools to guide treatment decisions. The goal is to help clinicians balance stroke prevention with bleeding risk in a personalized way.
Why it matters
Potential benefit: If successful, clinicians could tailor anticoagulation choices for ICH survivors with AF based on brain imaging, potentially improving safety and reducing recurrent events.
How similar studies have gone: Previous observational data suggest CSVD features influence risks, and this study extends those findings with larger, prospective data.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Falcone, Guido Jose — Yale University
- Study coordinator: Falcone, Guido Jose
Related research
Other NIH-funded projects on the same topics.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
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Investigating anticoagulation therapy for stroke survivors with specific brain conditions
This study is looking at how brain health affects the safety and success of blood-thinning treatments for people who have had a specific type of stroke and also have a heart condition, to help doctors make better treatment choices for these patients.
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Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
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Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
-
Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
-
Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.