Investigating anticoagulation therapy for stroke survivors with specific brain conditions
Official title: Anticoagulation in Intracerebral Hemorrhage Survivors with Atrial Fibrillation and Imaging Features of Cerebral Amyloid Angiopathy and Small Vessel Disease
Funded at Yale University · NIH-11142056 · Data updated 2026-11-12
This study is looking at how brain health affects the safety and success of blood-thinning treatments for people who have had a specific type of stroke and also have a heart condition, to help doctors make better treatment choices for these patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 9, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $631,465 |
| NIH project number | 1R01NS140459-01A1 |
| Project ID | NIH-11142056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have survived an intracerebral hemorrhage and have a diagnosis of atrial fibrillation, particularly those with specific brain imaging features.
✕Less likely to help
Patients who do not have a history of intracerebral hemorrhage or atrial fibrillation are unlikely to benefit from this research.
What this research studies
This research focuses on patients who have survived a type of stroke called intracerebral hemorrhage (ICH) and also have a heart condition known as atrial fibrillation (AF). The study aims to understand how different brain conditions, particularly cerebral small vessel disease (CSVD), affect the safety and effectiveness of anticoagulation therapy, which is used to prevent further strokes. By analyzing data from previous clinical trials and brain imaging, the researchers will develop tools to better guide treatment decisions for these patients. The goal is to identify which patients may benefit from anticoagulation therapy and which may be at increased risk of complications.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and safer anticoagulation treatment strategies for stroke survivors with atrial fibrillation.
How similar studies have gone: Previous research has indicated the importance of tailoring anticoagulation therapy based on individual patient characteristics, suggesting that this approach may yield significant insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Falcone, Guido Jose — Yale University
- Study coordinator: Falcone, Guido Jose
Related research
Other NIH-funded projects on the same topics.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
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Anticoagulation in ICH survivors with AF and small vessel disease features
A study to understand how anticoagulant therapy affects people who have had a non-traumatic brain bleed and also have atrial fibrillation, focusing on imaging signs of small vessel disease.
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Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
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Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
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Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
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Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.