Investigating anticoagulation therapy for stroke survivors with specific brain conditions
Anticoagulation in Intracerebral Hemorrhage Survivors with Atrial Fibrillation and Imaging Features of Cerebral Amyloid Angiopathy and Small Vessel Disease
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11142056
This study is looking at how brain health affects the safety and success of blood-thinning treatments for people who have had a specific type of stroke and also have a heart condition, to help doctors make better treatment choices for these patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11142056 on ClinicalTrials.gov |
What this research studies
This research focuses on patients who have survived a type of stroke called intracerebral hemorrhage (ICH) and also have a heart condition known as atrial fibrillation (AF). The study aims to understand how different brain conditions, particularly cerebral small vessel disease (CSVD), affect the safety and effectiveness of anticoagulation therapy, which is used to prevent further strokes. By analyzing data from previous clinical trials and brain imaging, the researchers will develop tools to better guide treatment decisions for these patients. The goal is to identify which patients may benefit from anticoagulation therapy and which may be at increased risk of complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have survived an intracerebral hemorrhage and have a diagnosis of atrial fibrillation, particularly those with specific brain imaging features.
Not a fit: Patients who do not have a history of intracerebral hemorrhage or atrial fibrillation are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and safer anticoagulation treatment strategies for stroke survivors with atrial fibrillation.
How similar studies have performed: Previous research has indicated the importance of tailoring anticoagulation therapy based on individual patient characteristics, suggesting that this approach may yield significant insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FALCONE, GUIDO JOSE — YALE UNIVERSITY
- Study coordinator: FALCONE, GUIDO JOSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Arterial Disorder