Aerobic exercise and muscle health to boost outcomes in colon cancer survivors
Official title: Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colon Cancer
Funded at Adventhealth Orlando · NIH-11085079 · Data updated 2026-11-12
A structured aerobic exercise program is tested to see if it improves muscle health and lowers cancer recurrence risk in people who have completed treatment for colon cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | June 3, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $675,689 |
| NIH project number | 5R01CA270274-05 |
| Project ID | NIH-11085079 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have completed treatment for colon cancer and are able to participate in an aerobic exercise program.
✕Less likely to help
Individuals unable to engage in regular aerobic activity or with medical contraindications to exercise may not benefit.
What this research studies
This project tests whether a supervised aerobic training plan can remodel skeletal muscle and reduce inflammation in colon cancer survivors. Participants will be randomly assigned to structured exercise or usual care, with measurements of muscle composition, metabolic function, and physical performance. The study aims to link improvements in muscle health with better cancer prognosis and fewer health problems after treatment. Results could help survivors adopt exercise as a strategy to support longevity and quality of life.
Why it matters
Potential benefit: If successful, survivors may gain a practical exercise approach to improve muscle health and possibly reduce recurrence and mortality risk.
How similar studies have gone: Previous research has shown associations between physical activity and better prognosis, with mechanistic studies suggesting muscle remodeling as a key factor.
Where this research is happening
-
Adventhealth Orlando
Orlando, United States Active
Researchers
- Principal investigator: Brown, Justin C — Adventhealth Orlando
- Study coordinator: Brown, Justin C
Related research
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-
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-
Adaptive aerobic exercise during colon cancer chemotherapy
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How aerobic exercise affects muscle health in colon cancer survivors
This study is looking at how a regular exercise program can help improve muscle health and strength in people who have survived colon cancer, with the goal of boosting their overall well-being and lowering the chances of cancer coming back.
-
Colon Cancer Family Registry Cohort study for smarter prevention and care
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.