NIH-funded research NIH-funded research

Aerobic exercise to boost stroke rehabilitation outcomes with a VR game

Official title: Priming the Rehabilitation Engine: Aerobic Exercise as the Fuel to Spark Behavioral Improvements in Stroke

Funded at Ralph H Johnson VA Medical Center · NIH-11493622 · Data updated 2026-11-12

A VA-based study tests whether an aerobic workout before a hand-rehabilitation game can improve recovery after stroke for veterans.

More Stroke research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionRalph H Johnson VA Medical Center
NIH-funded
Lab location1 site (Charleston, United States)
Project startFebruary 1, 2021
Project endJanuary 31, 2027
Funding year2027
NIH project number5IK2RX003540-06
Project IDNIH-11493622 on NIH RePORTER

Who could benefit from this research

Could help

Veterans and others recovering from stroke who would participate in upper-extremity rehabilitation using the Duck Duck Punch game.

Less likely to help

Patients not undergoing upper-extremity rehabilitation or those unable to participate in aerobic exercise may not benefit.

What this research studies

This project explores using aerobic exercise to ‘prime’ the brain before engaging in a targeted upper-extremity rehabilitation game called Duck Duck Punch. By combining aerobic activity with a virtual reality game, the researchers aim to create a brain environment that is more receptive to motor learning and recovery after stroke. The study focuses on veterans and measures functional and cognitive improvements, along with potential brain plasticity markers, to see if the prep workout enhances rehabilitation gains. If successful, this approach could become a practical addition to post-stroke care to maximize benefits from therapy sessions.

Why it matters

Potential benefit: If the approach works, veterans recovering from stroke could experience greater improvements in arm function and overall quality of life after rehabilitation.

How similar studies have gone: Prior evidence suggests aerobic exercise can support neuroplasticity and improve rehabilitation outcomes, with emerging data on priming effects.

Where this research is happening

  • Ralph H Johnson VA Medical Center
    Charleston, United States
    Active

Researchers

  • Principal investigator: Ross, Ryan — Ralph H Johnson VA Medical Center
  • Study coordinator: Ross, Ryan

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.